Table 2.

Odds ratios and 95% confidence intervals of tobacco use for polyps of the distal colon and rectum (Prostate, Lung, Colorectal, and Ovarian Trial, 1993-2000)

Tobacco useNo. controlsHyperplatic polyps only
Adenomas only
Concurrent hyperplastic polyps and adenomas
No. casesOR (95% CI)No. casesOR (95% CI)No. casesOR (95% CI)
Smoking status
    Never smoked15,010444882106
    Ever cigarette smokers15,8381,0402.1 (1.9-2.4)1,3431.2 (1.1-1.3)3642.3 (1.9-2.9)
    Current cigarette smokers2,2532784.4 (3.7-5.2)2751.8 (1.5-2.1)1126.2 (4.7-8.3)
    Ex cigarette smokers13,5857621.8 (1.6-2.1)1,0681.1 (1.0-1.2)2522.2 (1.7-2.8)
    Ex cigarette, current cigar/pipe users*341262.4 (1.5-3.6)281.0 (0.7-1.5)154.4 (2.5-7.9)
    Never cigarette but current cigar/pipe users*24960.7 (0.3-1.6)221.1 (0.7-1.7)41.6 (0.6-4.5)
    Never cigarette but ex cigar/pipe users*1,147541.4 (1.0-1.9)850.9 (0.7-1.2)232.0 (1.3-3.2)
Cigarettes smoked per day
    1-104,2631951.6 (1.3-1.9)2961.1 (1.0-1.3)632.0 (1.5-2.8)
    11-205,8983862.2 (1.9-2.5)4961.2 (1.1-1.3)1422.8 (2.2-3.7)
    21-303,0172452.7 (2.3-3.2)2861.3 (1.1-1.5)893.4 (2.5-4.6)
    ≥312,6362132.6 (2.2-3.1)2631.3 (1.1-1.5)702.9 (2.1-4.0)
    Ptrend<0.00010.040.05
Smoking duration (y)
    <154,0931471.2 (1.0-1.4)2581.0 (0.8-1.1)381.2 (0.8-1.7)
    15-243,7101561.4 (1.1-1.7)2621.0 (0.9-1.2)571.8 (1.3-2.5)
    25-343,2732372.4 (2.1-2.9)2801.2 (1.1-1.4)692.6 (1.9-3.5)
    35-443,2813333.5 (3.0-4.1)3411.5 (1.3-1.7)1154.3 (3.3-5.7)
    ≥45+1,1611524.2 (3.4-5.1)1781.8 (1.5-2.2)797.2 (5.2-10.0)
    Ptrend<0.0001<0.0001<0.0001
Pack-years
    1-95,0752041.4 (1.2-1.6)3221.0 (0.9-1.2)581.5 (1.1-2.1)
    10-192,9531491.7 (1.4-2.0)2391.1 (1.0-1.3)481.9 (1.4-2.8)
    20-292,4341612.3 (1.9-2.8)1871.1 (0.9-1.3)562.8 (2.0-4.0)
    30-391,8501773.2 (2.6-3.8)1931.4 (1.2-1.7)774.7 (3.5-6.5)
    40-541,4441453.5 (2.9-4.3)1561.5 (1.3-1.8)443.7 (2.5-5.3)
    ≥551,5731733.7 (3.0-4.5)2001.6 (1.4-1.9)694.8 (3.4-6.6)
    Ptrend<0.0001<0.0001<0.0001
Years since stopped smoking (y)
    ≥40832341.2 (0.8-1.7)651.0 (0.7-1.3)111.3 (0.7-2.4)
    30-<403,0161211.3 (1.0-1.6)2000.9 (0.8-1.1)321.2 (0.8-1.8)
    20-<303,6801491.3 (1.1-1.6)2601.0 (0.9-1.2)481.5 (1.1-2.2)
    10-<203,3902162.2 (1.8-2.6)2871.2 (1.1-1.4)712.6 (1.9-3.5)
    <102,4552353.3 (2.8-3.9)2381.4 (1.2-1.7)854.4 (3.2-5.9)
    Ptrend<0.0001<0.0001<0.0001
  • NOTE: ORs adjusted for age, sex, education, fruit, alcohol intake, and study centers. Ptrends presented were estimated by using logistic regression among ever smokers only.

    Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * ORs for cigar/pipe use were estimated among men only.