Table 3.

Statistical analysis of the study population by DNMT3b genotype

No stratificationStratified by age
<40 y≥40 y
n (colorectal cancer/total)74/14635/6039/86
Tests for homogeneity (P)
    Three genotypes
        Log rank0.0680.0640.017
        Wilcoxon0.3500.0650.007
        Fleming-Harrington0.0470.2290.052
        Cox analysis without robust0.0570.0980.010
        Cox analysis with robust0.0790.0540.028
Combined CT + TT genotypes
        Log rank0.0220.3420.005
        Wilcoxon0.1610.2390.009
        Fleming-Harrington0.0160.7610.055
        Cox analysis without robust0.0180.3560.003
        Cox analysis with robust0.0290.2810.007


HR (95% CI)
P
HR (95% CI)
P
HR (95% CI)
P
Without robust correction
    Heterozygotes (CT)2.07 (1.09-3.94)0.0261.88 (0.82-4.29)0.1333.71 (1.28-10.74)0.016
    SNP homozygotes (TT)1.88 (0.89-3.98)0.0990.82 (0.29-2.33)0.7164.46 (1.37-14.48)0.013
    Combined CT + TT2.02 (1.08-3.77)0.0271.44 (0.65-3.20)0.3703.88 (1.37-11.04)0.011
With robust correction
    Heterozygotes (CT)2.07 (1.10-3.91)0.0241.88 (0.90-3.91)0.0913.71 (1.41-9.78)0.008
    SNP homozygotes (TT)1.88 (0.86-4.08)0.1110.82 (0.39-1.74)0.6144.46 (1.27-15.63)0.020
    Combined CT + TT2.02 (1.07-3.80)0.0291.44 (0.74-2.80)0.2813.88 (1.44-10.48)0.008