Table 2.

Multivariate RR and 95% CI of OPLs, by average daily alcohol intake

RR (95% CI) per category of intake
RR (95% CI) with additional 12.5 g/d (∼1 drink)P value, test for trend ≥30 g/d
0 g/d0.1-4.9 g/d5.0-14.9 g/d15.0-29.9 g/d≥30 g/d
Any OPL (n)2146474633
    Cumulative average intake*1.001.72 (0.93-3.17)1.69 (0.88-3.22)2.89 (1.49-5.60)2.52 (1.25-5.07)1.22 (1.10-1.35)0.0002
    Baseline 1986 intake*3133533640
1.001.28 (0.63-2.60)1.70 (0.86-3.37)2.28 (1.12-4.65)2.36 (1.15-4.84)1.19 (1.08-1.31)0.0003
    Baseline 1986 intake with lag-time of 10 to 16 years§1412321524
1.001.23 (0.40-3.84)2.69 (0.94-7.67)2.53 (0.83-7.74)3.43 (1.15-10.21)1.20 (1.06-1.37)0.006
    OED, cumulative average intake (n)1221161718
1.001.16 (0.50-2.71)0.83 (0.33-2.09)1.63 (0.65-4.13)2.19 (0.85-5.63)1.29 (1.10-1.50)0.001
    OED, Baseline 1986 intake1513221420
1.000.83 (0.31-2.20)1.18 (0.47-2.96)1.56 (0.58-4.15)2.17 (0.83-5.67)1.28 (1.12-1.46)0.0004
  • NOTE: Risks are adjusted for age, follow-up cycle, pipe/cigar smoking status, chewing tobacco use, cigarette smoking status, years since quitting among past smokers, cigarettes smoked per day among current smokers, age at start of smoking, total energy intake, fruit intake, former drinker at baseline, and dental profession. The reference group includes nondrinkers (0 g/d). Cumulative average intake incorporates intake through 16 years (1986-2002) of follow-up. Baseline intake uses only 1986 intake levels to assess risk from 1986 to 2002. A single alcoholic beverage contains 11.0 to 14.0 g of alcohol.

  • * Analysis included 193 oral premalignant lesion events among 41,458 participants.

  • P < 0.01.

  • P = 0.02.

  • § Analysis used baseline 1986 alcohol consumption to assess disease risk from 1996 to 2002, and included 97 events among 41,458 participants.

  • Oral epithelial dysplasia analysis included only the 84 events with confirmed dysplasia among 41,395 participants, after excluding men with an oral premalignant lesion that did not undergo biopsy.