Table 2.

ORs for smoking, polymorphisms in PAH metabolism and conjugation genes, and prostate cancer

VariableAll subjects
Caucasians only
OR (95% CI)*POR (95% CI)*P
Smoking
    Never smoker1.00 (Reference)1.00 (Reference)
    Light smoker0.86 (0.58-1.27)0.450.98 (0.65-1.50)0.94
    Heavy smoker0.95 (0.67-1.36)0.791.05 (0.72-1.52)0.80
CYP1A1 Ile462Val
    Ile/Ile1.00 (Reference)1.00 (Reference)
    Ile/Val1.14 (0.53-2.45)0.741.07 (0.49-2.33)0.87
    Val/Val0.90 (0.13-6.37)0.910.85 (0.12-5.92)0.89
mEH His139Arg
    His/His1.00 (Reference)1.00 (Reference)
    His/Arg1.00 (0.66-1.52)0.991.02 (0.66-1.57)0.94
    Arg/Arg0.85 (0.37-1.96)0.701.07 (0.40-2.88)0.89
GSTP1 Ile105Val
    Ile/Ile1.00 (Reference)1.00 (Reference)
    Ile/Val1.22 (0.84-1.77)0.291.12 (0.76-1.65)0.57
    Val/Val0.86 (0.45-1.64)0.650.65 (0.34-1.25)0.20
GSTP1 Ala114Val
    Ala/Ala1.00 (Reference)1.00 (Reference)
    Ala/Val1.17 (0.71-1.92)0.540.43 (0.02-11.41)0.61
    Val/Val1.13 (0.68-1.88)0.630.43 (0.02-10.90)0.61
GSTM1 null deletion
    Null1.00 (Reference)1.00 (Reference)
    Nondeleted1.00 (0.69-1.45)0.991.09 (0.66-1.46)0.94
GSTT1 null deletion
    Null1.00 (Reference)1.00 (Reference)
    Nondeleted0.79 (0.47-1.31)0.360.71 (0.41-1.22)0.22
  • * All results are adjusted for age.

  • Light smokers: 1 to 20 pack-years; heavy smokers: >20 pack-years.

  • Includes subjects with at least one copy of the nondeleted (+) allele.