Table 1.

Characteristics of the family-based case-control study population

Cases (n = 439)Controls (n = 479)
Mean age, y (SD)61.5 (6.7)62.8 (9.1)
Ethnicity, %
    Caucasian397 (90%)437 (91%)
    African-American38 (9%)38 (8%)
    Other4 (1%)4 (1%)
Gleason score ≥ 7191 (44%)
Clinical tumor stage ≥ T2c55 (13%)
Smoking, %
    Never smokers161 (37%)173 (37%)
    Light smokers*114 (27%)125 (27%)
    Heavy smokers*154 (36%)170 (36%)
Metabolizing genotypes, %
    CYP1A1 462Ile/Ile404 (93%)445 (93%)
    CYP1A1 462Ile/Val29 (7%)30 (6%)
    CYP1A1 462Val/Val3 (<1%)4 (1%)
    mEH 139His/His292 (66%)317 (66%)
    mEH 139His/Arg121 (28%)131 (28%)
    mEH 139Arg/Arg25 (6%)27 (6%)
Conjugating genotypes, %
    GSTP1 105Ile/Ile175 (40%)207 (43%)
    GSTP1 105Ile/Val222 (50%)214 (45%)
    GSTP1 105Val/Val42 (10%)58 (12%)
    GSTP1 114Ala/Ala374 (85%)410 (86%)
    GSTP1 114Ala/Val64 (15%)67 (14%)
    GSTP1 114Val/Val1 (<1%)2 (<1%)
    GSTM1 nondeleted§222 (51%)241 (50%)
    GSTM1 null216 (49%)238 (50%)
    GSTT1 nondeleted§362 (83%)398 (83%)
    GSTT1 null76 (17%)81 (17%)
  • * Light smokers: ≤20 pack-years; heavy smokers: > 20 pack-years. Ten cases and 11 controls were missing smoking duration information.

  • Base pair notation for CYP1A1 Ile462Val is A4889G and for mEH His139Arg is A9970G.

  • Base pair notation for GSTP1 105Ile/Val and Ala114Val polymorphisms are A1578G and C2293T, respectively.

  • § Includes subjects with at least one copy of the nondeleted (+) allele.