Table 3.

Multivariate estimates of the association in controls among age, average physical activity level, fruit and vegetable intake, average lifetime alcohol intake, cigarette smoking status, BMI, and menopausal status and 15-F2t-IsoP and 8-oxodG levels in urine

Risk factor15-F2t-IsoP
8-oxodG
β (95% CI)*β (95% CI)β (95% CI)β (95% CI)*β (95% CI)β (95% CI)
Age (y)
    20-39ReferenceReferenceReferenceReference
    40-490.20 (−0.06-0.45)0.16 (−0.11-0.44)0.08 (−0.12-0.28)0.07 (−0.14-0.28)
    50-590.27 (0.02-0.52)0.08 (−0.29-0.45)0.19 (−0.01-0.39)−0.05 (−0.33-0.23)
    60+0.44 (0.20-0.68)0.22 (−0.17-0.61)0.19 (0.004-0.38)−0.09 (−0.39-0.20)
Average physical activity level (h/wk)
    0ReferenceReferenceReferenceReference
    <0.69−0.01 (−0.22-0.19)−0.02 (−0.23-0.20)0.04 (−0.12-0.20)0.05 (−0.11-0.22)
    0.70-2.6−0.04 (−0.25-0.16)−0.02 (−0.24-0.20)0.06 (−0.10-0.22)0.10 (−0.07-0.27)
    2.7+−0.004 (−0.21-0.20)−0.05 (−0.27-0.17)0.02 (−0.14-0.18)0.03 (−0.14-0.20)
Fruit and vegetable intake (no. 1/2 cup serving/wk)
    0-18ReferenceReferenceReferenceReference
    19-260.05 (−0.16-0.26)0.15 (−0.08-0.38)0.07 (−0.10-0.24)0.13 (−0.05-0.31)
    27-340.08 (−0.15-0.31)0.14 (−0.11-0.39)0.03 (−0.15-0.20)0.08 (−0.11-0.27)
    35-460.16 (−0.07-0.39)0.26 (0.002-0.51)0.01 (−0.16-0.19)0.002 (−0.19-0.20)
    47+0.08 (−0.16-0.31)0.15 (−0.11-0.40)0.01 (−0.17-0.19)0.06 (−0.13-0.26)
Average lifetime alcohol intake (g/d)
    NondrinkersReferenceReferenceReferenceReference
    <15−0.02 (−0.18-0.13)−0.07 (−0.24-0.10)0.07 (−0.06-0.19)0.06 (−0.07-0.19)
    15-300.09 (−0.19-0.38)0.03 (−0.30-0.37)0.13 (−0.09-0.35)−0.02 (−0.28-0.24)
    30+0.06 (−0.22-0.34)0.04 (−0.29-0.37)0.004 (−0.21-0.22)0.002 (−0.25-0.26)
Active cigarette smoking status
    NeverReferenceReferenceReferenceReferenceReferenceReference
    Current0.30 (0.11-0.50)0.32 (0.10-0.54)0.31 (0.10-0.52)0.23 (0.09-0.38)0.24 (0.07-0.41)0.21 (0.05-0.37)
    Former0.07 (−0.09-0.23)0.05 (−0.13-0.24)0.07 (0.10-0.24)0.17 (0.05-0.30)0.15 (0.01-0.29)0.15 (0.02-0.28)
BMI (kg/m2)
    <25ReferenceReferenceReferenceReference
    ≥25−0.09 (−0.23-0.05)−0.05 (−0.21-0.11)0.03 (−0.09-0.14)0.02 (−0.10-0.14)
Menopausal status
    PremenopausalReferenceReferenceReferenceReferenceReference
    Postmenopausal0.17 (−0.06-0.40)0.11 (−0.14-0.36)0.21 (0.03-0.39)0.24 (0.04-0.43)0.22 (0.04-0.42)
  • NOTE: Levels of 15-F2t-IsoP and 8-oxodG are log transformed (natural log).

  • * Adjusted for age.

  • Adjusted for age, average physical activity level, fruit and vegetable intake, average lifetime alcohol intake, active smoking status, BMI and menopausal status.

  • Best-fitting model.