Table 2.

Logistic regression analysis of MIC-1 immunostaining and clinicopathologic predictors of extraprostatic invasion in radical prostatectomy specimens

Risk factorUnivariate analysis
Multivariate analysis
Odds ratio (95% CI)POdds ratio (95% CI)P
ln(PSA)*1.5 (1.0-2.2)0.04831.3 (0.8-1.9)0.2825
Gleason score >62.8 (1.6-5.1)0.00062.4 (1.3-4.6)0.0060
MIC-1 immunostaining (% of cancer cells)
    0-19%4.4 (1.5-13.0)0.00683.8 (1.3-11.5)0.0176
    20-39%3.7 (1.2-11.4)0.02233.8 (1.2-12.1)0.0237
    40-59%6.0 (1.6-21.9)0.00675.2 (1.4-19.7)0.0158
    60-79%1.7 (0.6-5.0)0.32571.6 (0.5-4.9)0.3894
  • * Natural log of preoperative PSA.

  • Hazard ratios and Ps are in relation to reference category 80-99%.