Table 1.

Cox proportional hazards analyses of NPY immunostaining and clinicopathologic predictors of relapse after radical prostatectomy

Risk factorUnivariate analysis
Multivariate analysis
Hazard ratio (95% CI)PHazard ratio (95% CI)P
Pathologic stage >2C3.2 (1.9-5.5)<0.00013.1 (1.7-5.6)0.0002
ln(PSA)*2.1 (1.5-2.9)<0.00011.9 (1.4-2.7)<0.0001
Gleason score >62.0 (1.2-3.2)0.00691.4 (0.8-2.3)0.1935
Surgical margin involvement2.3 (1.3-3.8)0.00251.4 (0.7-2.5)0.3117
NPY immunostaining (% of cancer cells)
    80-99% (n = 15)2.5 (1.1-5.8)0.03033.1 (1.3-7.3)0.0103
    60-79% (n = 17)1.9 (0.9-4.3)0.10043.0 (1.3-6.9)0.0096
    40-59% (n = 26)1.5 (0.7-3.0)0.30061.7 (0.8-3.6)0.1434
    20-39% (n = 37)1.3 (0.7-2.5)0.44712.0 (1.0-4.1)0.0449
  • * Natural log of preoperative PSA.

  • Hazard ratios and Ps are in relation to reference category 0-19% (n = 95).