Table 2.

Joint association of MTR and MTRR genotypes and folate and folate cofactor intake with breast cancer risk among Chinese women, Shanghai Breast Cancer Study, 1996 to 1998

GenotypeCases/controls
Adjusted OR (95% CI)*
Cases/controls
Adjusted OR (95% CI)*
Cases/controls
Adjusted OR (95% CI)*
T1 (high)T2T3
Daily folate intake
    MTR A2756G
        AA236/2921.0 (Reference)299/2981.5 (1.1-2.0)280/2761.7 (1.2-2.4)
        AG/GG46/561.0 (0.7-1.6)61/511.8 (1.2-2.8)58/651.6 (1.0-2.5)
    MTRR A66G
        AA166/2091.0 (Reference)205/2101.4 (1.0-1.9)196/1991.6 (1.1-2.3)
        AG106/1340.9 (0.7-1.3)137/1311.6 (1.1-2.2)127/1301.6 (1.1-2.4)
        GG17/250.8 (0.4-1.5)26/162.4 (1.2-4.7)22/271.4 (0.8-2.7)
Daily methionine intake
    MTR A2756G
        AA312/2921.0 (Reference)233/2950.9 (0.7-1.2)270/2791.2 (0.8-1.7)
        AG/GG52/491.0 (0.7-1.6)56/551.1 (0.7-1.7)57/681.0 (0.6-1.7)
    MTRR A66G
        AA220/2091.0 (Reference)166/2160.8 (0.6-1.2)181/1931.2 (0.8-1.7)
        AG133/1340.9 (0.7-1.3)112/1201.0 (0.7-1.5)125/1411.1 (0.7-1.7)
        GG19/240.7 (0.4-1.3)25/221.4 (0.7-2.6)21/221.2 (0.6-2.3)
Daily vitamin B12 intake
    MTR A2756G
        AA285/3081.0 (Reference)273/2761.1 (0.8-1.4)257/2821.2 (0.8-1.5)
        AG/GG55/461.3 (0.8-2.0)53/640.9 (0.6-1.4)57/621.2 (0.8-1.8)
    MTRR A66G
        AA200/2051.0 (Reference)182/2080.9 (0.7-1.2)185/2051.1 (0.8-1.5)
        AG122/1341.0 (0.7-1.3)134/1301.1 (0.8-1.5)114/1311.1 (0.7-1.5)
        GG23/280.9 (0.5-1.6)19/230.8 (0.4-1.6)23/171.6 (0.8-3.1)
Daily vitamin B6 intake
    MTR A2756G
        AA303/2991.0 (Reference)267/2860.9 (0.7-1.2)246/2810.9 (0.6-1.3)
        AG/GG56/461.1 (0.8-1.8)55/620.9 (0.6-1.3)54/640.9 (0.6-1.4)
    MTRR A66G
        AA220/2051.0 (Reference)186/2140.8 (0.6-1.1)161/1990.7 (0.5-1.1)
        AG128/1420.8 (0.6-1.1)122/1200.9 (0.7-1.3)120/1330.9 (0.6-1.3)
        GG23/220.9 (0.5-1.6)23/230.9 (0.5-1.8)19/230.8 (0.4-1.6)
  • * All ORs are adjusted for age, history of fibroadenoma, waist-to-hip ratio, age at first live birth, physical activity, total meat intake, total energy intake, and intake of folate and/or its cofactors.