Table 1.

MTR, MTRR, and MTHFR genotype frequencies and adjusted OR (95% CI) for breast cancer among Chinese women, Shanghai Breast Cancer Study, 1996 to 1998

GenotypeTotal sample
MTHFR genotype
677CC
677CT
677TT
Cases/ControlsAdjusted OR (95% CI)*Cases/controlsAdjusted OR (95% CI)*Cases/controlsAdjusted OR (95% CI)*Cases/ControlsAdjusted OR (95% CI)*
MTR A2756G
    AA877/9321.0 (Reference)290/3061.0 (Reference)428/4271.1 (0.9-1.3)140/1461.0 (0.8-1.4)
    AG181/1951.0 (0.8-1.2)
    GG8/110.8 (0.3-2.0)
    AG/GG65/571.2 (0.8-1.8)88/1010.9 (0.7-1.3)32/331.1 (0.7-1.8)
MTRR A66G
    AA621/6871.0 (Reference)199/2101.0 (Reference)316/3261.0 (0.8-1.3)96/1190.8 (0.6-1.2)
    AG393/4221.0 (0.9-1.2)133/1391.0 (0.7-1.3)182/1881.0 (0.8-1.4)64/581.2 (0.8-1.8)
    GG70/761.0 (0.7-1.4)24/231.1 (0.6-2.0)29/360.8 (0.5-1.4)14/111.5 (0.6-3.4)
MTR/MTRR
    AA/AA482/5261.0 (Reference)164/1691.0 (Reference)236/2491.0 (0.7-1.3)75/920.8 (0.6-1.2)
    AA/AG or GG107/1081.0 (0.7-1.3)31/311.1 (0.6-1.8)59/581.0 (0.7-1.6)16/200.8 (0.4-1.6)
    AG or GG/AA359/3731.0 (0.9-1.3)117/1270.9 (0.7-1.3)174/1651.0 (0.8-1.5)58/501.2 (0.8-1.9)
    AG or GG/AG or GG75/851.0 (0.7-1.4)30/241.2 (0.7-2.2)27/430.6 (0.4-1.1)15/131.4 (0.6-3.0)
  • * All ORs are adjusted for age, history of fibroadenoma, waist-to-hip ratio, age at first live birth, physical activity, and total meat.