Table 2.

Cytogenetic characteristics of patients by Hispanic status

Cytogenetic characteristicB-lineage ALL
ALL
Hispanic
Non-Hispanic White
PTotal
N = 389 n (%)N = 151 n (%)N = 140 n (%)N = 356 n (%)
Structural changes
    t(12;21)74 (19.0)19 (12.6)34 (24.3)0.0172 (20.2)
    t(9;22)7 (1.8)2 (1.3)1 (0.7)1.07 (2.0)
    E2A translocation15 (3.9)7 (4.6)6 (4.3)0.8915 (4.2)
    11q23/MLL rearrangements14 (3.6)3 (2.0)4 (2.9)0.7114 (3.9)
    del(12p)13 (3.3)3 (2.0)3 (2.1)1.011 (3.1)
    del(11q)3 (0.8)0 (0)2 (1.4)0.142 (0.6)
    del(9p)13 (3.3)4 (2.7)4 (2.9)1.010 (2.8)
    del(7p)1 (0.3)0 (0)0 (0)1 (0.3)
    del(7q)1 (0.3)1 (0.7)0 (0)1.01 (0.3)
    del(6q)18 (4.6)6 (4.0)6 (4.3)0.8914 (3.9)
    del(5q)2 (0.5)0 (0)1 (0.7)0.481 (0.3)
    Any deletion47 (12.1)16 (10.6)16 (11.4)0.8239 (11.0)
    Total structural changes209 (53.7)69 (45.7)79 (56.4)0.07194 (54.5)
Numerical changes
    Constitutional trisomy 2114 (3.6)8 (5.3)5 (3.6)0.4814 (3.9)
    Trisomy 831 (8.0)16 (10.6)11 (7.9)0.4230 (8.4)
    -Y5 (1.3)2 (1.3)2 (1.4)1.05 (1.4)
    Monosomy 79 (2.3)1 (0.7)5 (3.6)0.117 (2.0)
    Total numerical changes250 (64.3)106 (70.2)95 (67.9)0.67241 (67.7)
Ploidy level*
    Diploid61 (15.7)23 (15.2)17 (12.1)0.4445 (12.6)
    Hyperdiploid (47-67)196 (50.4)83 (55.0)73 (52.1)0.63190 (53.4)
        High hyperdiploid (51-67)133 (34.2)62 (41.1)47 (33.6)0.19133 (37.3)
        Low hyperdiploid (47-50)63 (16.2)21 (13.9)26 (18.6)0.2857 (16.0)
    Hypodiploid 4522 (5.7)8 (5.3)10 (7.1)0.5121 (5.9)
    Hypodiploid <454 (1.0)1 (0.7)2 (1.4)0.613 (0.8)
    Pseudodiploid103 (26.5)34 (22.5)37 (26.4)0.4494 (26.4)
    Near triploid (68-80)3 (0.8)2 (1.3)1 (0.7)1.03 (0.8)
  • NOTE: Percentages do not add to 100% because patients may have more than one abnormality. Cases with inadequate karyotypes are not displayed: total, n = 62; too few, n = 2; no bone marrow sample, n = 15; diploid with fewer than 20 metaphases counted, n = 40; only FISH analysis was done and no aberration was identified, n = 5. For B-lineage ALL cases, a total of 65 cases having other ethnicities (n = 54) or unknown ethnicity (n = 11) are not displayed. P values are from Pearson's χ2 statistic or Fisher's exact test (two-tailed probabilities) when expected cell frequencies were five or less.

  • * Pearson's χ2 analysis comparing Hispanics and non-Hispanics: χ2 = 4.10, degrees of freedom = 6, P = 0.66.