Table 5.

ORs and 95% CIs associated with polymorphisms in selected metabolic genes

No. casesNo. controlsOR* (95% CI)OR (95% CI)
GSTM1
    −/+ or +/+6710511
    −/−991840.9 (0.6-1.3)0.8 (0.5-1.2)
All166283
CYP1A1*2A SNP (rs4646903)
    T/T265311
    T/C871551.2 (0.7-2.1)1.2 (0.7-2.0)
    C/C55781.5 (0.8-2.8)1.5 (0.8-2.7)
All168286
    Hardy Weinberg equilibrium test§P = 0.15
CYP1A1*2C SNP (rs1048943)
    Ile/Ile7813511
    Ile/Val791291.1 (0.7-1.6)1.0 (0.7-1.5)
    Val/Val10230.7 (0.3-1.6)0.8 (0.3-1.7)
All167287
    Hardy-Weinberg equilibrium test§P = 0.33
  • * Adjusted for sex and age. Two control sets pooled.

  • Adjusted for sex, age, and lifelong total tobacco smoked. Two control sets pooled.

  • Reference category.

  • § Exact probability.