Table 2.

Prevalence of genotypes of CYP3A5, PON1, PON2, GSTM1, GSTT1, and GSTP1 among pesticide-exposed fruit growers and controls stratified by pesticide exposure

Genotype
ControlsPesticide exposure
GeneAllelesLowHigh
No. subjects1064348
CYP3A5A−44A55 (51.9%)*26 (60.5%)26 (54.2%)
A−44G41 (38.7%)16 (37.2%)21 (43.7%)
G−44G10 (9.4%)1 (2.3%)1 (2.1%)
PON1Gln-Gln43 (40.6%)12 (27.9%)21 (43.7%)
Arg-Gln34 (32.1%)13 (30.2%)19 (39.6%)
Arg-Arg29 (27.3%)18 (41.9%)8 (16.7%)
PON2Cys-Cys2 (1.9%)2 (4.6%)1 (2.1%)
Cys-Ser32 (30.2%)11 (25.6%)15 (31.2%)
Ser-Ser72 (67.9%)30 (69.8%)32 (66.7%)
GSTM1Null67 (63.2%)23 (53.5%)22 (45.8%)
Non-null39 (36.8%)20 (46.5%)26 (54.2%)
GSTT1Null46 (43.4%)20 (46.5%)24 (50.0%)
Non-null60 (56.6%)23 (53.5%)24 (50.0%)
GSTP1Ile-Ile56 (52.8%)27 (62.8%)30 (62.5%)
Ile-Val43 (40.6%)14 (32.6%)16 (33.3%)
Val-Val7 (6.6%)2 (4.6%)2 (4.2%)
  • * Data represent the numbers of subjects (with percentage in parentheses, where shown).