Type* (cases) | β | φ_{1} | φ_{2} | P^{†} | β^{‡} | P^{§} |
---|---|---|---|---|---|---|

SQ (2,411) | 0.0247 | 2.26 | −0.404 | <0.001 | 0.00914 | 0.50 |

SM (795) | 0.000395 | 4.65 | −0.788 | <0.001 | 0.00583 | 0.22 |

LG (336) | 0.00365 | 3.38 | −0.642 | <0.001 | 0.00416 | 0.07 |

AD (562) | 0.000297 | 3.87 | −0.656 | 0.01 | 0.00141 | 0.81 |

NOTE: Model: EOR =

*β*×*d*×exp{*φ*_{1}ln(*n*) +*φ*_{2}ln(*n*)^{2}}, where*d*is pack-years of exposure and*n*is cigarettes smoked per day. All models were adjusted for center, age, and sex.↵* Histologic types include squamous cell carcinoma (SQ), small cell carcinoma (SM), large cell carcinoma (LG), and adenocarcinoma (AD).

↵†

*P*value for hypothesis test of no intensity effects,*φ*_{1}= 0 and*φ*_{2}= 0.↵‡ Estimated EOR/pack-year with

*φ*_{1}and*φ*_{2}fixed at their values based on all cases and controls; i.e.,*φ*_{1}= 2.89 and*φ*_{2}= −0.504.↵§

*P*value for the 2 degree of freedom likelihood ratio test of fit with*β*estimated and*φ*_{1}and*φ*_{2}fixed at their values from all data.