Table 3.

OR (95% CI) of breast cancer in premenopausal and postmenopausal women according to quartiles of energy-adjusted folate, vitamin B6, and vitamin B12 intake

Quartiles of intake
1234P trend
Folate
    Premenopausal women
        Cases/controls58/18947/15541/16143/181
        Median intake (μg/d)218303360460
            Multivariable-adjusted*1.000.88 (0.53-1.44)0.80 (0.47-1.36)0.73 (0.42-1.27)0.26
    Postmenopausal women
        Cases/controls104/15866/19356/18860/166
        Median intake (mg/d)229302363458
            Multivariable-adjusted*1.000.72 (0.47-1.09)0.59 (0.38-0.91)0.55 (0.35-0.86)0.008
Vitamin B6
    Premenopausal women
        Cases/controls71/18333/14537/15248/206
        Median intake (μg/d)1.051.261,401.60
            Multivariable-adjusted*1.000.57 (0.34-0.95)0.66 (0.40-1.10)0.76 (0.46-1.26)0.34
    Postmenopausal women
        Cases/controls90/16567/20566/18563/150
        Median intake (mg/d)1.071.261.391.59
            Multivariable-adjusted*1.000.80 (0.53-1.22)0.89 (0.57-1.37)0.94 (0.59-1.49)0.87
Vitamin B12
    Premenopausal women
        Cases/controls64/20654/15644/16727/157
        Median intake (μg/d)2.645.67.7
            Multivariable-adjusted*1.001.11 (0.69-1.80)0.65 (0.38-1.10)0.54 (0.29-0.99)0.01
    Postmenopausal women
        Cases/controls95/14685/18763/18143/191
        Median intake (μg/d)2.64.15.77.3
            Multivariable-adjusted*1.000.64 (0.42-0.98)0.35 (0.21-0.58)0.21 (0.12-0.37)<0.0001
  • * Adjusted for age, socioeconomic status, family breast cancer, parity, availability of BMI, total caloric intake, dietary fiber, carbohydrate intake, and polyunsaturated fat intake.