Table 3.

SIRs for ovarian cancer in first-degree relatives of cancer patients, by patients' cancer site and BRCA mutation status

Patient's BRCA statusPatient's cancer site
P*
Breast cancer (n = 670)
Ovarian cancer (n = 342)
No.OESIR (95% CI)No.OESIR (95% CI)
BRCA1-positive4820.37.9 (1.2-53.0)7650.411.3 (3.6-35.9)0.37
BRCA2-positive4720.44.6 (0.6-38.0)
Negative/untested1,8833437.80.9 (0.5-1.4)881136.81.9 (1.0-4.0)0.04
All1,9783842.21.0 (0.7-1.4)957187.22.5 (1.6-4.0)
  • * Two-tailed test of similar SIRs in relatives of breast and ovarian cancer patients.

  • BRCA2 testing was not done among ovarian cancer patients.