Table 4.

HR of developing selected cancers and of dying in relatives of cases of NHL compared with relatives of controls according to selected characteristics of the index case/control (Italy, 1999-2002)

Characteristic of the index case/controlEvent in relatives
All lymphomas
HLP cancers*
All cancers
All deaths
NHR (95% CI)NHR (95% CI)NHR (95% CI)NHR (95% CI)
Males
    Controls (2,704)117115918131
    NHL (879)27.0 (0.6-77.0)73.4 (1.2-9.7)791.7 (1.3-2.3)2421.0 (0.9-1.1)
Females
    Controls (1,216)214110413731
    NHL (792)32.4 (0.4-14.6)72.9 (0.8-9.9)831.3 (1.0-1.8)2421.0 (0.9-1.2)
Age <50 y
    Controls (757)011132111
    Case (433)347.1 (0.8-63.3)352.0 (1.2-3.2)651.6 (1.1-2.2)
Age ≥50 y
    Controls (3,163)31101231111
    Case (1,238)21.8 (0.3-11.1)102.7 (1.1-6.4)1271.5 (1.2-1.9)4191.0 (0.9-1.1)
All controls (3,920)3111127311,1861
NHL by
    Histologic subtype
        Follicular (283)28.6 (1.4-51.4)22.3 (0.5-10.2)321.7 (1.1-2.4)710.8 (0.7-1.1)
        Diffuse (837)24.3 (0.7-25.9)105.5 (2.3-13.1)811.7 (1.4-2.2)2541.1 (0.9-1.3)
        T-cell (131)110.5 (1.1-101)12.9 (0.4-22.8)121.6 (0.9-2.8)300.9 (0.7-1.4)
        Other (420)010.9 (0.1-6.9)371.4 (1.0-2.0)1291.0 (0.8-1.2)
    Grade (B-cell NHL only)
        Low (574)24.6 (0.8-27.8)31.8 (0.5-6.5)591.6 (1.2-2.1)1611.0 (0.8-1.1)
        Intermediate/high (914)23.8 (0.6-22.6)104.9 (2.1-11.6)871.7 (1.3-2.1)2751.1 (0.9-1.2)
        Unknown (52)0041.2 (0.5-3.3)180.9 (0.5-1.4)
    Primary site
        Nodal (1,131)5114.4 (1.9-10.1)1221.9 (1.6-2.4)3211.1 (0.9-1.2)
        Extranodal (540)031.9 (0.5-6.6)401.1 (0.8-1.5)1630.9 (0.8-1.1)
  • NOTE: Estimates from proportional hazard models adjusted for sex of the relative. Reference category: relatives of controls.

  • * HLP cancers including lymphomas.

  • Reference category.