Table 4.

OR of RCC according to family history of selected cancers in first-degree relatives: Italy, 1992-2004

Cancer site in the relativeSubjects with family history (%)
OR (95% CI)
RCC (n = 767)Controls (n = 1,534)
Oral cavity21 (2.7)33 (2.2)1.3 (0.7-2.2)
Esophagus6 (0.8)15 (1.0)0.9 (0.4-2.4)
Stomach49 (6.4)74 (4.8)1.4 (0.9-2.0)
Intestine (chiefly colorectum)39 (5.0)63 (4.0)1.4 (0.9-2.1)
Liver32 (4.2)60 (3.9)1.1 (0.7-1.7)
Gallbladder2 (0.3)3 (0.2)1.1 (0.1-8.3)
Pancreas11 (1.4)30 (2.0)0.8 (0.4-1.7)
Larynx9 (1.2)14 (0.9)1.5 (0.6-3.7)
Lung58 (7.6)88 (6.1)1.3 (0.9-1.9)
Bone0 (0.0)6 (0.4)
Skin, including melanoma7 (0.3)6 (0.4)2.3 (0.8-6.9)
Breast41 (5.3)65 (2.8)1.3 (0.9-2.0)
Uterus26 (3.4)32 (2.1)1.6 (0.9-2.7)
Ovary5 (0.7)3 (0.2)3.9 (0.9-16.6)
Prostate19 (2.5)21 (0.9)1.9 (1.0-3.6)
Bladder6 (0.8)15 (1.0)0.8 (0.3-2.2)
Brain17 (2.2)21 (0.9)1.6 (0.8-3.0)
Lymphomas7 (0.9)12 (0.8)1.2 (0.5-3.0)
Leukemias19 (2.5)17 (1.1)2.2 (1.1-4.2)
All sites321 (41.9)520 (33.9)1.5 (1.2-1.8)
    Excluding kidney307 (40.0)514 (33.9)1.4 (1.1-1.7)
  • NOTE: ORs from conditional logistic regression, conditioned on age, sex, and study center and adjusted for year of interview, education, smoking, BMI, and number of brothers. Reference category: no family history of the investigated cancer.