Table 2.

OR of RCC and 95% CI for a family history of kidney cancer in first-degree relatives, also according to some characteristics of the affected relative: Italy, 1992-2004

RCC (n = 767)Controls (n = 1,534)OR (95% CI)
Family history of kidney cancer
No749 (97.6)1,526 (99.5)1*
Yes18 (2.3)8 (0.5)5.2 (2.2-12.2)
Sex of affected relative
    Male8 (1.0)5 (0.3)4.1 (1.3-13.0)
    Female10 (1.3)3 (0.2)6.8 (1.8-25.6)
Youngest age at diagnosis in relatives (y)
    <609 (1.2)4 (0.3)5.1 (1.5-17.1)
    ≥608 (1.0)2 (0.1)10.0 (2.1-48.1)
Relative affected
    Parent/son10 (1.3)5 (0.3)4.3 (1.5-12.9)
    Brother8 (1.0)3 (0.2)7.0 (1.8-27.7)
  • NOTE: ORs from conditional logistic regression, conditioned on age, sex, and study center and adjusted for year of interview, education, smoking, BMI, and number of brothers and sisters.

  • * Reference category.

  • For some relatives, age at diagnosis was unknown.