Table 6.

Gene-gene interaction of polymorphism Y133H in EPHX1 with CY1A1 m4 and deletion of GSTT1

Gene and polymorphismEPHX1 Y113H
P for interaction*
TT/TC, OR (95% CI)CC, OR (95% CI)
Overall
    CYP1A1CC1.00 (reference)2.13 (1.30-3.48)
    m4 (T461N)AA/CA1.60 (0.98-2.62)0.98 (0.11-9.02)0.25
    GSTT1Present1.00 (reference)1.90 (1.14-3.18)
    del{GSTT1}Null1.13 (0.74-1.73)2.38 (0.67-8.42)0.89
Never smokers
    CYP1A1CC1.00 (reference)1.61 (0.65-4.01)
    m4 (T461N)AA/CA0.96 (0.42-2.22)
    GSTT1Present1.00 (reference)1.20 (0.43-3.34)
    del{GSTT1}Null1.97 (1.03-3.75)8.49 (1.01-71.4)0.30
Ever smokers
    CYP1A1CC1.00 (reference)2.42 (1.31-4.47)0.92
    m4 (T461N)AA/CA2.37 (1.24-4.54)4.86 (0.25-95.7)
    GSTT1Present1.00 (reference)2.33 (1.24-4.38)
    del{GSTT1}Null0.85 (0.46-1.54)1.23 (0.22-6.82)0.62
  • * By likelihood ratio test.

  • OR (and 95% CI) estimated by unconditional logistic regression, adjusted by sex, age, center, and date of blood extraction. Ever smokers further adjustment by cigarettes/day and duration of smoking.