Table 5.

OR and 95% CI of gastric adenocarcinoma for SNPs in metabolic genes according to smoking status, by localization, and by histologic type

GenePolymorphismModelOverall, OR* (95% CI)Never smokers, OR* (95% CI)Ever smokers, OR* (95% CI)P for homogeneity
Cardia (68 cases, 250 controls)
    CYP1A1m1CC/TC vs TT0.94 (0.47-1.86)1.81 (0.39-8.32)0.65 (0.26-1.60)0.17
    CYP1A1m4 (T461N)AA/CA vs CC1.71 (0.67-4.36)1.89 (0.35-10.1)2.31 (0.59-9.12)0.95
    CYP1A2−3859G>AAA/GA vs GG1.47 (0.25-8.50)6.90 (0.16-299)1.29 (0.12-14.3)0.56
    EPHX1Y113HCC vs TC/TT1.84 (0.79-4.32)1.91 (0.72-5.07)
    GSTT1del{GSTT1}Null vs present0.82 (0.38-1.79)0.37 (0.06-2.38)0.97 (0.34-2.78)0.70
Noncardia (128 cases, 507 controls)
    CYP1A1m1CC/TC vs TT0.79 (0.46-1.36)1.31 (0.58-2.98)0.48 (0.20-1.14)0.11
    CYP1A1m4 (T461N)AA/CA vs CC1.44 (0.76-2.71)0.97 (0.34-2.80)1.91 (0.74-4.91)0.36
    CYP1A2−3859G>AAA/GA vs GG2.13 (0.69-6.64)3.08 (0.62-15.2)2.32 (0.37-14.4)0.87
    EPHX1Y113HCC vs TC/TT2.64 (1.41-4.95)2.94 (0.99-8.78)3.07 (1.29-7.33)0.90
    GSTT1del{GSTT1}Null vs present1.15 (0.68-1.92)2.94 (1.30-6.67)0.70 (0.31-1.56)0.04
Diffuse (93 cases, 366 controls)
    CYP1A1m1CC/TC vs TT0.71 (0.37-1.35)1.19 (0.44-3.27)0.46 (0.17-1.27)0.12
    CYP1A1m4 (T461N)AA/CA vs CC0.43 (0.15-1.25)0.39 (0.08-1.84)0.44 (0.09-2.13)0.95
    CYP1A2−3859G>AAA/GA vs GG2.41 (0.67-8.66)9.59 (1.39-66.1)
    EPHX1Y113HCC vs TC/TT1.43 (0.63-3.29)2.33 (0.72-7.49)1.14 (0.28-4.69)0.34
    GSTT1del{GSTT1}Null vs present0.87 (0.44-1.72)1.75 (0.60-5.26)0.59 (0.20-1.72)0.22
Intestinal (94 cases, 365 controls)
    CYP1A1m1CC/TC vs TT0.57 (0.29-1.12)1.34 (0.38-4.78)0.39 (0.15-1.04)0.14
    CYP1A1m4 (T461N)AA/CA vs CC3.03 (1.60-5.73)3.48 (0.95-12.8)4.35 (1.67-11.3)0.66
    CYP1A2−3859G>AAA/GA vs GG1.60 (0.31-8.25)3.27 (0.46-23.1)
    EPHX1Y113HCC vs TC/TT2.38 (1.24-4.56)2.12 (0.34-13.2)2.68 (1.18-6.11)0.54
    GSTT1del{GSTT1}Null vs present1.20 (0.65-2.22)3.85 (1.15-12.5)0.63 (0.25-1.56)0.03
  • * OR (95% CI) by unconditional logistic regression, adjusted by sex, age, center, and date of blood extraction plus cigarettes/day and duration of smoking (ever smokers). OR (95% CI) for ever smokers (adjusted by education, Hp infection, and the intake of vegetables, citrus fruit, and meat): cardia, 2.03 (1.01-4.07); noncardia, 1.86 (1.17-2.96); diffuse, 1.66 (1.00-2.76); and intestinal, 1.71 (0.95-3.05).