Table 3.

OR and 95% CI of gastric adenocarcinoma for SNPs in metabolic genes

GenePolymorphismModelEffectReferenceOR (95% CI)*OR (95% CI)
CYP1A11,188 bp 3′ of STP T>C (m1)GenotypeTCTT0.74 (0.49-1.10)0.74 (0.49-1.11)
CCTT
DominantCC/TCTT0.70 (0.47-1.04)0.70 (0.47-1.06)
Ex7+131A>G (I462V, m2)GenotypeAGAA0.82 (0.44-1.51)0.90 (0.48-1.68)
GGAA
DominantGG/AGAA0.88 (0.49-1.60)0.98 (0.53-1.80)
Ex7+129C>A (T461N, m4)GenotypeCACC1.57 (0.99-2.50)1.55 (0.96-2.50)
AACC
DominantAA/CACC1.53 (0.96-2.43)1.51 (0.94-2.43)
CYP1A2IVS1-154A>CGenotypeACAA1.27 (0.94-1.71)1.29 (0.95-1.76)
CCAA1.01 (0.56-1.82)1.02 (0.56-1.88)
DominantCC/ACAA1.23 (0.92-1.65)1.26 (0.93-1.70)
RecessiveCCAC/AA0.89 (0.51-1.56)0.89 (0.50-1.59)
−3859G>AGenotypeGAGG1.92 (0.79-4.65)2.12 (0.85-5.31)
AAGG
DominantAA/GAGG1.92 (0.79-4.65)2.12 (0.85-5.31)
EPHX1Ex3-28T>C (Y113H)GenotypeTCTT1.15 (0.85-1.56)1.11 (0.81-1.51)
CCTT2.05 (1.25-3.37)1.96 (1.18-3.26)
DominantCC/TCTT1.27 (0.95-1.68)1.22 (0.91-1.63)
RecessiveCCTC/TT1.91 (1.19-3.07)1.87 (1.14-3.04)
Ex4+52A>G (H139R)GenotypeAGAA1.07 (0.78-1.46)1.07 (0.78-1.48)
GGAA0.90 (0.45-1.82)0.94 (0.46-1.92)
DominantGG/AGAA1.04 (0.78-1.40)1.06 (0.78-1.43)
RecessiveGGAG/AA0.88 (0.44-1.77)0.92 (0.45-1.86)
GSTT1del{GSTT1}NullPresent1.13 (0.76-1.67)1.05 (0.70-1.57)
  • * OR (95% CI) by conditional logistic regression; matching variables: sex, age, center, and date of blood extraction.

  • OR as (*) and further adjusted for Hp infection, total meat, total vegetables and citrus fruit intake, and educational level.