Table 2.

Frequency distribution of genotypes for polymorphisms in metabolic genes in gastric adenocarcinoma cases and controls

GenePolymorphismGenotypeCases, n (%)Controls, n (%)
CYP1A1*1,188 bp 3′ of STP T>C (m1) rs4646903TT210 (86.4)765 (81.4)
TC33 (13.6)167 (17.8)
CC8 (0.9)
Total243940
Ex7+131A>G (I462V, m2) rs1048943AA229 (94.2)874 (93.4)
AG13 (5.3)62 (6.6)
GG1 (0.4)0 (0.0)
Total243936
Ex7+129C>A (T461N, m4) rs1799814CC216 (88.9)864 (92.3)
CA27 (11.1)69 (7.4)
AA3 (0.3)
Total243936
CYP1A2IVS1-154A>C rs762551AA111 (45.9)474 (50.3)
AC115 (47.5)399 (42.3)
CC16 (6.6)70 (7.4)
Total242943
−3859G>A rs2069514GG235 (96.7)926 (98.0)
GA8 (3.3)19 (2.0)
AA
Total243945
EPHX1Ex3-28T>C (Y113H) rs1051740TT105 (43.2)453 (48.3)
TC110 (45.3)422 (45.0)
CC28 (11.5)62 (6.6)
Total243937
Ex4+52A>G (H139R) rs2234922AA156 (64.5)615 (65.1)
AG76 (31.4)289 (30.6)
GG10 (4.1)40 (4.2)
Total242944
GSTT1del{GSTT1}Present205 (84.7)801 (85.9)
Null37 (15.3)131 (14.1)
Total242932
  • * SNP m1 and m2 in linkage disequilibrium: r2 = 0.23, D′ = 0.86 (P < 0.001).