Table 5.

Multivariable-adjusted HRs for NHL, leukemia, and multiple myeloma mortality associated with BMI and plasma glucose level in the Chicago Heart Association Detection Project in Industry, 1967-1973

Risk factorsNHL
Leukemia
Multiple myeloma
Model 1
Model 2
Model 1
Model 2
Model 1
Model 2
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
Men
BMI*,
    Q1 (≤24.12)1.01.01.01.01.01.0
    Q2 (24.13-26.30)1.94 (0.91-4.12)1.84 (0.86-3.92)1.43 (0.75-2.74)1.40 (0.73-2.68)0.97 (0.34-2.77)0.99 (0.35-2.83)
    Q3 (26.31-28.61)2.08 (0.99-4.39)1.93 (0.91-4.08)2.13 (1.16-3.90)2.06 (1.12-3.79)1.55 (0.61-3.98)1.61 (0.63-4.13)
    Q4 (≥28.62)2.57 (1.24-5.34)2.31 (1.10-4.81)1.98 (1.07-3.69)1.89 (1.01-3.53)1.52 (0.59-3.92)1.62 (0.63-4.19)
    Ptrend0.010.030.020.030.290.22
Plasma glucose level (mg/dL)§
    ≤1191.01.01.01.01.01.0
    120-1591.81 (1.02-3.21)1.72 (0.97-3.04)1.75 (1.08-2.83)1.67 (1.03-2.71)1.42 (0.70-2.88)1.36 (0.67-2.77)
    160-1992.07 (1.07-4.00)1.89 (0.98-3.67)1.23 (0.66-2.30)1.14 (0.61-2.13)0.42 (0.12-1.51)0.39 (0.11-1.42)
    ≥2002.86 (1.35-6.06)2.60 (1.22-5.52)1.97 (1.00-3.87)1.82 (0.93-3.58)0.54 (0.12-2.46)0.50 (0.11-2.29)
    Ptrend<0.010.010.110.180.220.18
Women
BMI*,
    Q1 (≤20.98)1.01.01.01.01.01.0
    Q2 (20.99-23.24)0.73 (0.34-1.54)0.73 (0.35-1.55)1.03 (0.35-3.09)1.04 (0.35-3.10)1.67 (0.42-6.73)1.69 (0.42-6.80)
    Q3 (23.25-26.15)0.42 (0.18-0.99)0.42 (0.18-0.99)1.68 (0.63-4.50)1.68 (0.63-4.50)2.07 (0.55-7.85)2.06 (0.54-7.83)
    Q4 (≥26.16)0.47 (0.21-1.08)0.48 (0.21-1.09)2.47 (0.96-6.36)2.43 (0.94-6.30)2.00 (0.52-7.65)1.97 (0.51-7.53)
    Ptrend0.070.070.020.020.400.47
Plasma glucose level (mg/dL)§
    ≤1191.01.01.01.01.01.0
    120-1590.82 (0.41-1.64)0.85 (0.42-1.69)1.04 (0.51-2.09)0.98 (0.49-1.98)0.94 (0.36-2.42)0.91 (0.35-2.36)
    160-1990.83 (0.34-2.01)0.89 (0.36-2.15)1.01 (0.41-2.48)0.93 (0.38-2.28)0.94 (0.28-3.12)0.91 (0.27-3.00)
    ≥2001.57 (0.61-4.02)1.65 (0.64-4.25)2.26 (0.91-5.64)2.10 (0.84-5.22)3.06 (1.05-8.93)2.98 (1.02-8.68)
    Ptrend0.590.490.160.230.080.09
  • NOTE: HRs from Cox proportional hazards regression.

  • * Weight (kg)/height (m)2.

  • model 1 adjusted for six categories of age (≤49, 50-54, 55-59, 60-64, 65-69, and ≥70 y), education (<high school, high school, and >high school), smoking (never, former, and current), and race (African American versus white/other, multiple myeloma males only). model 2 adjusted for all variables in model 1 and postload glucose level (4 levels).

  • P for trend was computed by modeling the within-category mean level of each risk factor as a continuous variable.

  • § model 1 adjusted for six categories of age (≤49, 50-54, 55-59, 60-64, 65-69, and ≥70 y), education (<high school, high school, and >high school), and smoking (never, former, and current). model 2 adjusted for all variables in model 1 and body mass index (quartiles).