Table 2.

Least-squares mean (95% confidence limits) plasma IGF-I, IGFBP-3, and IGF-I/IGFBP-3 molar ratio levels (ng/mL) by BMI category (by race/ethnicity)

BMI (kg/m2)
<2525-29.99≥30Ptrend
IGF-I*
    Latino184.6 (164.7-205.7)147.7 (134.8-161.4)132.7 (115.2-151.7)0.0002
    White184.9 (168.4-202.3)155.2 (139.9-171.4)151.3 (130.1-174.5)0.009
    Japanese American173.7 (161.8-186)166.5 (150.2-183.9)122.9 (91.3-160.2)0.04
    African American172.2 (149.5-196.9)172.3 (153.3-192.5)172.9 (150.6-197.1)0.97
    Native Hawaiian166.0 (147.8-185.4)184.6 (167.9-202.2)179.4 (162-197.8)0.35
IGFBP-3
    Latino2,498 (2,252-2,756)2,488 (2,306-2,676)2,279 (2,031-2,541)0.25
    White2,847 (2,635-3,067)2,881 (2,664-3,106)2,938 (2,620-3,275)0.66
    Japanese American2,860 (2,687-3,039)2,783 (2,542-3,034)3,112 (2,487-3,806)0.92
    African American2,609 (2,369-2,861)2,549 (2,355-2,752)2,718 (2,476-2,971)0.55
    Native Hawaiian2,744 (2,488-3,013)2,971 (2,746-3,205)2,807 (2,570-3,054)0.79
IGF molar ratio
    Latino0.28 (0.25-0.30)0.22 (0.21-0.24)0.21 (0.19-0.24)0.002
    White0.24 (0.22-0.26)0.20 (0.18-0.22)0.19 (0.17-0.22)0.002
    Japanese American0.22 (0.21-0.24)0.22 (0.20-0.24)0.17 (0.13-0.21)0.09
    African American0.24 (0.21-0.27)0.25 (0.23-0.27)0.24 (0.22-0.27)0.80
    Native Hawaiian0.22 (0.20-0.25)0.23 (0.21-0.25)0.24 (0.22-0.27)0.22
  • * IGF-I is adjusted for covariates found to be significant in a multivariate analysis (gender, age, race/ethnicity, BMI, and the interaction between race/ethnicity and BMI).

  • IGFBP-3 is adjusted for covariates found to be significant in a multivariate analysis (age, race/ethnicity, fat intake from meat, and BMI).

  • IGF molar ratio is adjusted for covariates found to be significant in a multivariate analysis (race/ethnicity, gender, BMI, and the interaction between race/ethnicity and BMI).