Table 2.

Risk of colorectal cancer associated with ERCC6 genotype stratified by cancer location

PolymorphismNo. PYColorectal cancer
Colon cancer
Proximal colon cancer
Distal colon cancer
Rectal cancer
No. casesRR (95% CI)No. casesRR (95% CI)No. casesRR (95% CI)No. casesRR (95% CI)No. casesRR (95% CI)
M1097V
    MM18,4261371.01081.0541.0481.0291.0
    MV8,680801.37 (1.00-1.87)631.37 (0.97-1.94)341.47 (0.94-2.32)231.13 (0.67-1.90)171.35 (0.73-2.50)
    VV1,212212.49 (1.42-4.36)172.56 (1.39-4.69)113.28 (1.59-6.77)51.70 (0.64-4.53)42.24 (0.76-6.63)
    Ptrend0.0010.0020.0020.350.13
R1213G
    RR18,4931351.01071.0521.0481.0281.0
    RG8,815801.36 (1.00-1.86)631.36 (0.96-1.91)371.63 (1.04-2.55)200.96 (0.56-1.65)171.37 (0.74-2.55)
    GG1,211222.64 (1.53-4.58)192.88 (1.60-5.17)123.72 (1.84-7.53)62.03 (0.82-5.04)31.73 (0.51-5.87)
    Ptrend0.00060.00090.00030.420.22
R1230P
    R23,3722051.01641.0891.0641.0411.0
    RP5,632440.84 (0.58-1.21)330.78 (0.52-1.18)170.74 (0.43-1.28)130.80 (0.43-1.49)111.07 (0.54-2.10)
    PP33000000
    Ptrend0.130.100.150.300.89