Table 6.

Association of aspirin or NSAID use with incident lung cancer by histologic type, IWHS, 1992-2002

Histologic type
Small cell
Squamous
Adenocarcinoma
Other
n = 65 cases; n = 26,414 noncases
n = 73 cases; n = 26,406 noncases
n = 142 cases; n = 26,357 noncases
n = 106 cases; n = 26,353 noncases
Adjusted HR (95% CI)Adjusted HR (95% CI)Adjusted HR (95% CI)Adjusted HR (CI 95%)
Aspirin use
    Never1.001.001.001.00
    ≤1 weekly1.46 (0.70-3.06)0.60 (0.28-1.29)1.24 (0.77-2.01)1.049 (0.68-1.61)
    2-5 weekly1.34 (0.58-3.13)1.18 (0.57-2.45)0.80 (0.43-1.50)0.68 (0.38-1.19)
    6+ weekly1.46 (0.68-3.13)1.31 (0.68-2.51)1.50 (0.92-2.45)0.64 (0.38-1.07)
Ptrend0.740.210.160.14
NSAID use
    Never1.001.001.001.00
    ≤1 weekly0.92 (0.45-1.85)1.24 (0.64-2.40)1.05 (0.66-1.60)0.62 (0.36-1.08)
    2-5 weekly0.63 (0.19-2.06)1.80 (0.83-3.91)1.26 (0.66-2.39)1.00 (0.52-1.93)
    6+ weekly0.94 (0.41-2.12)0.91 (0.40-2.06)1.13 (0.65-1.95)1.32 (0.82-2.14)
Ptrend0.900.450.890.17
  • NOTE: Adjusted for age (61-65, 66-70, and 71+ years), education (<high school, high school, and >high school), alcohol intake (continuous), smoking status (never, past, and current), pack-years (0, 1-19, 20-39, and 40+), BMI (continuous), total fruit servings weekly (continuous), and any heart disease/heart attack (yes and no).

    Aspirin analyses adjusted for NSAID use and NSAID analyses adjusted for aspirin use.