Table 5.

Association of aspirin and NSAID use and incident lung cancer by pack-years of smoking, IWHS, 1992-2002

Pack-years
0
<40
40+
n = 73 cases; n = 18,134 noncases
n = 144 cases; n = 6,161 noncases
n = 169 cases; n = 1,798 noncases
Adjusted HR (95% CI)Adjusted HR (95% CI)Adjusted HR (95% CI)
Aspirin use
    Never1.001.001.00
    ≤1 weekly1.06 (0.58-1.95)0.87 (0.55-1.35)1.14 (0.73-1.80)
    2-5 weekly0.97 (0.47-2.02)0.76 (0.44-1.32)0.89 (0.51-1.54)
    6+ weekly0.71 (0.33-1.54)1.06 (0.66-1.68)1.34 (0.86-2.08)
Ptrend0.770.660.41
NSAID use
    Never1.001.001.00
    ≤1 weekly0.85 (0.42-1.72)0.96 (0.61-1.52)0.92 (0.57-1.47)
    2-5 weekly1.57 (0.70-3.52)0.83 (0.42-1.66)1.25 (0.70-2.22)
    6+ weekly1.28 (0.61-2.66)0.91 (0.53-1.56)1.18 (0.73-1.88)
Ptrend0.590.950.74
  • NOTE: Adjusted for age (61-65, 66-70, and 71+ years), education (<high school, high school, and >high school), alcohol intake (continuous), BMI (continuous), total fruit servings weekly (continuous), and any heart disease/heart attack (yes and no). Aspirin analyses adjusted for NSAID use and NSAID analyses adjusted for aspirin use.