Table 3.

Association of aspirin or non-aspirin NSAID use with lung cancer incidence, IWHS, 1992-2002

No. casesTotal person-yearsAge-adjusted HR* (95% CI)Multivariate-adjusted HR* (95% CI)Multivariate-adjusted HR* (95% CI)
Aspirin use
    Never11073,6581.001.001.00 (1.00)
    ≤1 weekly12689,7670.96 (0.74-1.25)1.10 (0.84-1.43)1.01 (0.77-1.35)
    2-5 weekly5847,6150.83 (0.60-1.14)0.87 (0.63-1.21)0.85 (0.60-1.19)
    6+ weekly10955,0461.34 (1.02-1.74)1.21 (0.92-1.59)1.08 (0.81-1.45)
Ptrend0.010.220.58
NSAID use
    Never241160,6231.001.001.00
    ≤1 weekly6849,6520.93 (0.71-1.22)0.99 (0.75-1.30)0.92 (0.68-1.24)
    2-5 weekly3321,5031.04 (0.72-1.50)1.10 (0.76-1.60)1.16 (0.79-1.70)
    6+ weekly6134,3081.16 (0.88-1.54)1.23 (0.92-1.65)1.10 (0.80-1.51)
Ptrend0.640.530.71
  • * Aspirin analyses adjusted for NSAID use and NSAID analyses adjusted for aspirin use.

  • Adjusted for age (61-65, 66-70, and 71+), education (<high school, high school, and >high school), alcohol intake (continuous), smoking status (never, past, and current), pack-years (0, 1-19, 20-39, and 40+), BMI (continuous), and total fruit servings weekly (continuous).

  • Adjusted for age (61-65, 66-70, and 71+), education (<high school, high school, and >high school), alcohol intake (continuous), smoking status (never, past, and current), pack-years (0, 1-19, 20-39, and 40+), BMI (continuous), total fruit servings weekly (continuous), and history of heart disease/heart attack (yes and no).