Table 1.

Mean hormone concentrations (95% confidence interval) by category of blood pressure during the second and third trimesters and change in blood pressure between the second and third trimesters

nDHEAS (μg/dL)Androstenedione (ng/dL)Testosterone (ng/dL)Estradiol (pg/mL)Estriol (ng/mL)
Average for second trimester
    Diastolic (mmHg)
        <682696.5 (64.4-145)414 (304-563)189 (134-267)16,710 (12,276-22,746)13.8* (10.6-17.8)
        68-712681.0 (59.0-111)353 (277-449)143 (109-187)24,664 (19,369-31,407)20.7* (16.9-25.3)
        >7126104 (69.4-154)304 (224-412)130 (92.7-183)24,464 (18,031-33,192)16.1 (12.4-20.7)
        P for trend0.460.920.710.220.81
    Systolic (mmHg)
        <1122670.5 (46.9-106)255* (187-348)101*,† (71.2-142)28,834 (21,147-39,316)23.3*,† (18.0-30.3)
        112-11826108 (78.7-149)344*,† (269-439)161* (122-211)19,057 (14,919-24,344)14.1* (11.4-17.3)
        >11826106 (72.5-155)506*,† (379-675)217*,† (158-300)18,349 (13,749-24,487)13.9*,† (10.9-17.8)
        P for trend0.260.060.060.990.24
    MAP (mmHg)
        <832691.8 (51.0-165)360 (229-564)182 (129-257)23,445 (14,356-38,289)17.5 (11.2-27.4)
        83-8625125 (82.4-190)422 (307-580)147 (87.9-246)23,754 (16,780-33,626)17.8 (13.0-24.4)
        >862791.0 (49.1-169)304 (190-487)149 (96.1-229)22,557 (13,479-37,748)15.8 (9.9-25.2)
        P for trend0.550.260.200.300.92
Average for third trimester
    Diastolic (mmHg/wk)
        <702898.5 (66.9-145)392 (292-527)161 (115-223)23,036 (17,148-30,946)18.6 (14.5-23.8)
        70-732885.7 (59.2-124)279* (211-370)134 (97.7-184)19,090 (14,391-25,323)14.8 (11.7-18.7)
        >732895.9 (70.9-130)405* (322-510)164 (126-212)22,927 (18,204-28,875)16.6 (13.7-20.2)
        P for trend0.420.250.690.440.88
    Systolic (mmHg/wk)
        <11428106 (72.3-156)323 (241-433)136 (98.1-189)16,820 (12,531-22,577)12.1*,† (9.5-15.5)
        114-1202887.1 (58.4-130)379 (280-515)148 (105-208)27,816 (20,506-37,732)22.3* (17.3-28.9)
        >1202887.3 (64.6-118)362 (288-456)174 (135-225)21,550 (17,120-27,127)16.9*,† (13.9-20.5)
        P for trend0.690.990.520.230.39
    MAP (mmHg)
        <8428102 (60.5-172)368 (247-548)148 (96.1-229)21,555 (13,935-33,341)16.7 (11.2-24.8)
        84-892881.0 (54.0-122)332 (243-452)155 (111-218)23,227 (16,560-32,580)16.5 (12.2-22.5)
        >8928126 (69-231)378 (238-599)168 (101-277)25,091 (15,156-41,538)17.8 (11.2-28.1)
        P for trend0.780.960.580.220.53
Change from second to third trimester
    Diastolic (mmHg/wk)
        ≤026109 (83.0-144)336 (266-424)140 (109-180)24,022 (19,470-29,638)15.5* (12.8-18.7)
        0.1-0.452691.3 (70.1-119)410 (328-512)174 (137-220)24,319 (19,895-29,728)20.1*,† (16.8-24.1)
        >0.452688.5 (66.4-118)311 (245-396)137 (105-177)18,576 (14,942-23,093)15.2*,† (12.5-18.4)
        P for trend0.500.510.850.110.74
    Systolic (mmHg/wk)
        ≤02874.8* (57.1-97.9)359 (286-450)154 (120-196)20,411 (16,639-25,040)17.1 (14.3-20.6)
        0.1-0.5423111* (84.0-147)377 (297-477)167 (130-216)19,911* (16,083-24,651)14.9* (12.3-18.0)
        >0.5425106 (80.6-140)318 (252-401)129 (101-166)26,701* (21,629-32,963)18.5* (15.3-22.4)
        P for trend0.130.310.260.290.75
    MAP (mmHg/wk)
        ≤023118 (77.4-181)411 (297-568)184 (129-262)24,130 (16,924-34,403)14.0 (10.2-19.4)
        0.1-0.442690.1 (62.0-131)349 (262-465)145 (107-199)23,686 (17,333-32,369)20.0 (15.1-26.6)
        >0.442798.0 (58.4-164)321 (217-477)145 (94.0-222)21,979 (14,288-33,811)17.5 (11.8-25.9)
        P for trend0.980.150.160.300.37
  • Abbreviations: DHEAS, dehydroepiandrosterone sulfate; MAP, mean arterial pressure.

  • *† Means are significantly different at the P < 0.05 level.