Table 3.

Associations between common haplotypes in blocks 1 to 3 of IGFBP1 and IGFBP3 and breast cancer risk

Haplotype percentages in cases/controls (%)
OR (95% CI)
African Americans (n = 345/426)Native Hawaiians (n = 109/209)Japanese Americans (n = 425/420)Latinos (n = 335/386)Whites (n = 401/440)All groups (0 vs 1 copy) *All groups (0 vs 2 copies) *
Block 1
    1AGGCGA16/1920/1516/1920/1718/191.03 (0.88-1.20)0.83 (0.58-1.20)
    1BAGCGG11/1114/1715/1325/2525/270.91 (0.78-1.06)1.22 (0.86-1.75)
    1CAGGGG29/2718/2227/2922/2523/220.88 (0.76-1.02)1.03 (0.78-1.37)
    1DAACGA8/925/2625/2417/1921/201.00 (0.86-1.16)0.89 (0.63-1.26)
    1EGGCAG15/1515/136/54/33/31.06 (0.86-1.30)2.17 (1.10-4.29)
    1FGGCGG4/36/47/88/99/81.03 (0.83-1.27)4.32 (0.87-21.35)
    1GAGCGA7/81/11/10.94 (0.62-1.43)0.49 (0.06-4.25)
Block 2
    2AACACATTTC31/2935/3433/3426/2426/260.95 (0.83-1.10)1.19 (0.93-1.52)
    2BACACACTTC23/2314/1623/2033/3732/330.97 (0.84-1.13)0.98 (0.75-1.27)
    2CGCACGCTTC7/731/3228/2615/1719/171.01 (0.87-1.18)1.03 (0.73-1.47)
    2DGCGCGCCGT3/38/813/139/713/131.08 (0.90-1.30)0.74 (0.37-1.51)
    2EGTACGCTGT5/70/00/00/00/00.78 (0.50-1.21)
    2FGCATGCTTT12/120/00/01/10/01.04 (0.75-1.45)0.89 (0.28-2.83)
    2GGCGCGCCGC0/04/51/20/00/00.71 (0.41-1.22)
    2HGCATGCCGT1/13/20/08/74/41.14 (0.84-1.54)0.57 (0.14-2.33)
    2IGCACGCCGT5/50/00/00/00/00.80 (0.49-1.31)
Block 3
    3AGGACTGT33/3149/5276/7531/3236/400.93 (0.79-1.09)0.93 (0.76-1.14)
    3BAGGGGTT8/616/1311/1140/3922/201.23 (1.05-1.44)1.01 (0.72-1.41)
    3CAGGGGGG12/1210/141/117/1921/200.89 (0.75-1.06)1.31 (0.81-2.11)
    3DGGAGTGT18/212/20/04/45/40.85 (0.67-1.09)0.98 (0.48-2.01)
    3EGGAGGGT8/84/50/05/413/120.98 (0.78-1.22)1.82 (0.74-4.45)
    3FAAGGGTT3/417/1110/111/11/10.97 (0.76-1.25)1.94 (0.79-4.77)
    3GAGGGGGT8/70/00/00/00/01.27 (0.84-1.90)0.37 (0.04-3.03)
  • NOTE: ORs are estimated by unconditional logistic regression adjusted for age and ethnicity.

  • * Reference groups for each comparison are noncarriers of each haplotype.

  • n = cases/controls.

  • P < 0.05.