Table 2.

Associations between common haplotypes in blocks 1 to 3 of IGFBP1 and IGFBP3 and prostate cancer risk

Haplotype percentages in cases/controls (%)
OR (95% CI)
African Americans (n = 683/650)Native Hawaiians (n = 71/68)Japanese Americans (n = 462/471)Latinos (n = 647/649)Whites (n = 457/452)All groups (0 vs 1 copy)*All groups (0 vs 2 copies)*
Block 1
    1AGGCGA20/2016/1715/1716/1720/180.99 (0.87-1.13)0.92 (0.67-1.27)
    1BAGCGG11/1019/2014/1622/2625/270.89 (0.78-1.01)0.85 (0.64-1.15)
    1CAGGGG28/2718/2530/2525/2224/241.11 (0.97-1.25)1.18 (0.93-1.48)
    1DAACGA7/930/2124/2421/2017/190.97 (0.85-1.11)1.02 (0.74-1.41)
    1EGGCAG15/1511/126/74/43/20.99 (0.83-1.19)0.80 (0.40-1.59)
    1FGGCGG4/44/29/710/99/91.23 (1.03-1.47)0.95 (0.44-2.03)
    1GAGCGA8/80/00/00/00/00.99 (0.72-1.35)4.97 (0.57-43.23)
Block 2
    2AACACATTTC30/2830/3832/3526/2327/251.09 (0.96-1.23)1.23 (0.99-1.53)
    2BACACACTTC24/2314/1822/2332/3433/330.95 (0.84-1.09)0.90 (0.72-1.12)
    2CGCACGCTTC6/636/2326/2719/1815/161.03 (0.90-1.19)1.07 (0.76-1.50)
    2DGCGCGCCGT5/39/1212/137/914/131.07 (0.91-1.25)0.48 (0.25-0.94)
    2EGTACGCTGT0/00/00/00/00/0
    2FGCATGCTTT14/150/00/00/00/00.93 (0.73-1.19)0.87 (0.42-1.78)
    2GGCGCGCCGC0/00/00/00/00/0
    2HGCATGCCGT0/00/00/07/70/00.99 (0.78-1.27)0.26 (0.05-1.28)
Block 3
    3AGGACTGT33/3254/5775/7630/3140/381.03 (0.90-1.18)1.00 (0.84-1.20)
    3BAGGGGTT7/413/1011/1041/4119/241.07 (0.92-1.23)0.94 (0.73-1.21)
    3CAGGGGGG13/1413/171/116/1620/210.91 (0.78-1.05)0.98 (0.66-1.46)
    3DGGAGTGT20/222/30/04/46/40.93 (0.77-1.12)0.99 (0.59-1.64)
    3EGGAGGGT8/72/20/06/611/101.12 (0.93-1.35)1.96 (0.83-4.62)
    3FAAGGGTT5/414/1112/111/11/11.08 (0.86-1.35)1.47 (0.59-3.70)
    3GAGGGGGT7/80/00/01/10/01.02 (0.76-1.38)1.28 (0.19-8.63)
  • NOTE: ORs are estimated by unconditional logistic regression adjusted for age and ethnicity.

  • * Reference groups for each comparison are noncarriers of each haplotype.

  • n = cases/controls.

  • P < 0.05.