Table 1.

Odds Ratios and 95% CIs of prostate and breast cancer for IGFBP3 (A-202C)

IGFBP3 (A-202C)Prostate cancer analysis
Breast cancer analysis
Cases, n (%)Controls, n (%)OR (95% CI)Cases, n (%)Controls, n (%)OR (95% CI)
All*
    AA687 (30.1)720 (31.9)1.00502 (32.1)598 (31.2)1.00
    AC1002 (44.0)954 (42.3)1.09 (0.95-1.26)673 (43.0)891 (46.4)0.94 (0.79-1.10)
    CC590 (25.9)581 (25.8)1.06 (0.90-1.26)389 (24.9)431 (22.5)1.15 (0.94-1.41)
African Americans
    AA217 (32.6)224 (34.9)1.0097 (29.9)132 (31.6)1.00
    AC308 (46.3)298 (46.4)1.07 (0.84-1.37)115 (47.8)209 (50.0)1.01 (0.72-1.41)
    CC141 (21.2)120 (18.7)1.22 (0.90-1.66)72 (22.2)77 (18.4)1.28 (0.84-1.93)
Hawaiians
    AA22 (31.4)24 (35.8)1.0029 (28.2)97 (34.3)1.00
    AC36 (52.2)33 (49.3)1.14 (0.53-2.42)51 (49.5)121 (42.8)1.36 (0.80-2.32)
    CC12 (17.1)10 (14.9)1.23 (0.44-3.46)23 (22.3)65 (23.0)1.14 (0.61-2.16)
Japanese Americans
    AA264 (58.0)282 (60.5)1.00254 (60.9)234 (56.9)1.00
    AC161 (35.4)161 (34.6)1.05 (0.80-1.39)138 (33.1)158 (38.4)0.81 (0.61-1.08)
    CC30 (6.6)23 (4.9)1.37 (0.77-2.42)25 (6.0)19 (43.2)1.19 (0.64-2.22)
Latinos
    AA81 (12.7)95 (14.9)1.0045 (13.6)53 (14.0)1.00
    AC277 (43.5)257 (40.4)1.26 (0.89-1.77)147 (44.6)172 (45.3)1.02 (0.65-1.61)
    CC279 (43.8)284 (44.7)1.15 (0.82-1.62)138 (41.8)155 (40.8)1.06 (0.67-1.69)
Whites
    AA103 (22.8)95 (21.4)1.0077 (19.7)82 (19.2)1.00
    AC220 (48.8)205 (46.2)0.98 (0.70-1.38)182 (46.7)231 (54.0)0.84 (0.58-1.21)
    CC128 (28.4)144 (32.4)0.81 (0.56-1.17)131 (33.6)115 (26.9)1.25 (0.84-1.88)
  • NOTE: IGFBP3 (A-202C) (rs2854744) A/C alleles are of the reverse strand.

  • * ORs are estimated by unconditional logistic regression adjusted for age and ethnicity.

  • ORs are estimated by unconditional logistic regression adjusted for age.