Table 5.

Associations between waist circumference and risk of low-grade and high-grade prostate cancer, stratified by treatment and family history of prostate cancer, the PCPT

Variablesn (cases/controls)Waist circumference (cm), OR (95% CI)
PtrendContinuous model (per 10 cm)
<9595-100101-107≥108
Placebo arm
    Family history
        No869/3,4951.001.07 (0.86-1.32)1.06 (0.84-1.33)0.87 (0.64-1.18)0.560.95 (0.84-1.08)
        Yes223/6591.001.08 (0.68-1.71)1.45 (0.88-2.40)2.12 (1.10-4.11)0.021.40 (1.05-1.87)
    No family history
        Low grade672/3,4951.000.98 (0.77-1.25)1.07 (0.83-1.39)0.80 (0.56-1.14)0.380.96 (0.83-1.11)
        High grade197/3,4951.001.07 (0.69-1.66)0.94 (0.59-1.52)0.94 (0.52-1.72)0.960.90 (0.71-1.14)
    Have family history
        Low grade175/6591.000.98 (0.58-1.67)1.62 (0.92-2.85)2.54 (1.20-5.40)0.011.45 (1.05-2.02)
        High grade*48/6591.31 (0.76-2.32)
Finasteride arm
    Family history
        No553/3,4401.000.79 (0.61-1.03)0.71 (0.54-0.94)0.66 (0.46-0.94)0.010.86 (0.74-1.00)
        Yes155/6361.000.90 (0.53-1.52)1.49 (0.87-2.57)1.11 (0.55-2.22)0.361.02 (0.76-1.36)
    No family history
        Low grade339/3,4401.000.78 (0.57-1.07)0.71 (0.50-1.01)0.51 (0.32-0.82)0.010.78 (0.64-0.94)
        High grade214/3,4401.000.84 (0.56-1.27)0.66 (0.42-1.05)0.83 (0.48-1.45)0.290.92 (0.73-1.16)
    Have family history
        Low grade102/6361.000.76 (0.40-1.43)1.28 (0.67-2.45)0.77 (0.32-1.82)0.950.96 (0.68-1.38)
        High grade*53/6361.15 (0.72-1.86)
  • NOTE: Associations adjusted for age, race, diabetes, and BMI.

  • * Model could not be fit due to small numbers in certain cells.