Table 3.

Associations of anthropometric variables with risk of prostate cancer, the PCPT

VariablesQuartiles*
Ptrend
1234
Height (m)<1.721.72-1.781.79-1.82≥1.83
    Total prostate cancer1.001.07 (0.94-1.23)1.07 (0.93-1.23)1.22 (1.05-1.43)0.03
    Low-grade cancer1.001.05 (0.90-1.23)1.05 (0.90-1.24)1.25 (1.04-1.50)0.04
    High-grade cancer1.001.17 (0.92-1.47)1.11 (0.87-1.42)1.18 (0.88-1.57)0.28
Weight (kg)<78.078.0-85.785.8-95.2≥95.3
    Total prostate cancer1.001.06 (0.93-1.22)1.06 (0.92-1.22)1.06 (0.92-1.23)0.42
    Low-grade cancer1.000.95 (0.81-1.13)1.01 (0.86-1.19)0.91 (0.77-1.08)0.45
    High-grade cancer1.001.37 (1.07-1.77)1.16 (0.90-1.51)1.44 (1.11-1.86)0.03
BMI (kg/m2)<25.025.0-26.927.0-29.9≥30
    Total prostate cancer1.000.91 (0.79-1.05)0.96 (0.83-1.10)0.96 (0.83-1.10)0.67
    Low-grade cancer1.000.88 (0.74-1.04)0.88 (0.75-1.04)0.82 (0.69-0.98)0.03
    High-grade cancer1.000.97 (0.75-1.27)1.09 (0.85-1.40)1.29 (1.01-1.67)0.04
Waist (cm)<9595-100101-107≥108
    Total prostate cancer1.000.98 (0.85-1.13)1.02 (0.89-1.18)0.93 (0.81-1.18)0.50
    Low-grade cancer1.000.94 (0.79-1.11)1.00 (0.85-1.18)0.78 (0.66-0.93)0.02
    High-grade cancer1.001.05 (0.81-1.37)1.01 (0.77-1.31)1.27 (0.98-1.63)0.09
Waist/hip ratio<0.900.90-0.930.94-0.99≥1.00
    Total prostate cancer1.000.96 (0.76-1.21)1.01 (0.82-1.24)0.98 (0.80-1.22)0.94
    Low-grade cancer1.000.95 (0.73-1.23)0.92 (0.72-1.16)0.87 (0.68-1.11)0.21
    High-grade cancer1.000.93 (0.61-1.42)1.04 (0.71-1.52)1.11 (0.76-1.64)0.25
Waist/thigh ratio<1.701.70-1.791.80-1.91≥1.92
    Total prostate cancer1.001.03 (0.89-1.19)0.96 (0.83-1.11)0.97 (0.84-1.13)0.52
    Low-grade cancer1.000.99 (0.84-1.17)0.90 (0.75-1.07)0.93 (0.78-1.10)0.26
    High-grade cancer1.001.17 (0.90-1.51)1.07 (0.82-1.39)1.08 (0.83-1.41)0.75
  • Note: Associations are adjusted for age, race, treatment, diabetes, and family history of prostate cancer in first-degree relatives.

  • * A total of 1,936 cases (1,300 low-grade cancer cases, 521 high-grade cancer cases, and 115 with unknown Gleason score) and 8,322 controls.

  • Quartiles of BMI were also consistent with standard clinical definitions of obesity.

  • Categories based on cut points selected after examination of variable distribution. n in each category: total (675, 1,634, 4,211, 3,478), low-grade cancer (640, 1,551, 3,939, 3,249) and high-grade cancer (579, 1,411, 3,610, 3,017).