Height, weight, and BMI and risk of breast cancer before and after adjustment for percentage of mammographic density: matched analysis
Variable | All subjects (n = 1,114 pairs) | Premenopausal group (n = 162 pairs) | Postmenopausal group (n = 727 pairs) | ||||||
---|---|---|---|---|---|---|---|---|---|
β (SE)* | P† | β (SE) | P | β (SE) | P | ||||
Height‡ (cm), not adjusted for density | 0.0007 (0.007) | 0.92 | 0.0003 (0.016) | 0.98 | 0.0082 (0.009) | 0.34 | |||
Height§ (cm), adjusted for density | 0.0006 (0.007) | 0.94 | 0.0066 (0.017) | 0.70 | 0.0072 (0.009) | 0.41 | |||
Weight‡ (kg), not adjusted for density | 0.0032 (0.004) | 0.41 | −0.0119 (0.010) | 0.21 | 0.0084 (0.005) | 0.09 | |||
Weight§ (kg), adjusted for density | 0.0139 (0.004) | 0.001 | 0.0036 (0.011) | 0.73 | 0.0185 (0.006) | 0.001 | |||
BMI‡ (not adjusted for density) | 0.0080 (0.011) | 0.45 | −0.0387 (0.028) | 0.17 | 0.0159 (0.014) | 0.24 | |||
BMI§ (adjusted for density) | 0.0392 (0.012) | 0.001 | 0.0053 (0.031) | 0.87 | 0.0446 (0.015) | 0.003 |
↵* β is the maximum likelihood estimate of the variable.
↵† P value: test for β = 0.
↵‡ Adjusted for the following risk factors: age at menarche, age at first birth, parity, number of live births, menopausal status, age at menopause, hormone replacement therapy (ever/never), breast cancer in first-degree relatives (0, 1, 2+). Menopausal status was omitted from the analysis for the separate menopausal groups, and age at menopause from the analysis of the premenopausal group.
↵§ Adjusted for the risk factors above and percentage of mammographic density.