Table 1.

Demographic characteristics and frequencies of CMA/B A/G and CEA I/D polymorphisms

H. pylori-negative (n = 132)Gastritis alone (n = 160)Gastric ulcer (n = 127)Duodenal ulcer (n = 105)Gastric cancer (n = 119)P
Age, y (mean ± SD)53.8 ± 1.051.4 ± 0.952.3 ± 1.150.0 ± 1.268.6 ± 9.7<0.001
Sex (male/female, n/n)83/49109/51105/2187/1894/25<0.001
Histology
    Intestinal type87
    Diffuse type32
Clinical stage
    Stage I-II80
    Stage III-IV29
CMA/B polymorphism
    G/G genotype102 (77.3%)114 (71.3%)83 (65.4%75 (71.4%)67 (56.3%)0.003
    G/A genotype27 (20.5%)44 (27.5%)36 (28.3%)26 (24.8%)45 (37.8%)
    A/A genotype3 (2.2%)2 (1.2%)8 (6.3%)4 (3.8%)7 (5.9%)
ACE polymorphism
    I/I genotype50 (37.9%)51 (31.9%)50 (39.4%)41 (39.0%)54 (45.4%)0.129
    I/D genotype60 (45.5%)83 (51.9%)63 (49.6%)54 (51.4%)53 (44.5%)
    D/D genotype22 (16.6%)26 (16.2%)14 (11.0%)10 (9.6%)12 (10.1%)