Table 2.

Association of serum androgens and sex hormone binding globulin concentrations with risk of prostate cancer in a cohort of 794 men in the Baltimore Longitudinal Study of Aging, 1958 to 2003

Quartile
Ptrend*
1234
Testosterone
    Range (ng/dL)≤352353-418419-495>495.0
    RR1.000.741.190.860.31
    95% CI0.44-1.240.73-1.960.43 to 1.73
DHEAS
    Range (ng/dL)≤754755-1,2501,251-1,940>1,940
    RR1.001.060.671.650.36
    95% CI0.68-1.670.36-1.230.27-1.58
SHBG
    Range (nmol/L)≤63.163.2-79.179.2-98.7>98.7
    RR1.001.060.860.700.42
    95% CI0.60-1.080.50-1.500.39-1.29
Free testosterone (by mass action equation)
    Range (ng/dL)≤3.603.61-4.504.51-5.7>5.70
    RR1.001.521.162.590.03
    95% CI0.93-2.500.61-2.201.28-5.25
Free testosterone (by mass action equation)
    Range (ng/dL)≤3.403.41-4.234.24-5.2>5.20
    RR1.001.331.261.890.03
    95% CI0.78-2.250.68-2.330.99-3.61
Free testosterone index
    Range≤0.1480.149-0.2120.213-0.285>0.285
    RR1.001.861.901.340.05
    95% CI1.12-3.091.02-3.550.52-3.44
Free testosterone index*
    Range≤0.1350.136-0.1860.187-0.245>0.245
    RR1.002.682.872.260.04
    95% CI1.57-4.561.55-5.291.05-4.87
  • * By log likelihood ratio test.

  • Adjusted for age.

  • Excluding measures in men <45 years of age.