Table 2.

Genetic alterations in the 27 serrated adenomas

Patient no.SexAgeSize (mm)LocationGradeK-ras mutationAllelic imbalanceMSI-H
2p3p5q17p18q
1M628AHGDNINI
2M718DLGD
3M828DLGDNIAI
4M705SLGD
5M546SLGDNINI
6F688THGD
7F757AHGDAI
8F723DLGD12 Val (GTT)*NINI
9M426DLGDAI
10M683SLGDAI
11F685ALGD12 Asp (GAT)
12M734RLGDAI
13M539RLGDAI
14F758DLGDNIAI
15M388TLGD
16M685RHGDAI
17F836SLGDAIAIMSI
18F775SLGDAI
19M558DLGDAIAI
20M805AHGD
21M716AHGDNI
22M705DLGDAI
23M703TLGDAI
24M775DLGDNI
25F467ALGD
26M514RLGDNINIMSI
27F754SLGDNINIMSI
  • NOTE: 12 Asp, codon 12 aspartic acid; 12 Val, codon 12 valine; (−), no mutation, no allelic imbalance, or no MSI; NI, not informative (i.e., only one allele length obtained at PCR).

  • Abbreviations: A, ascending colon; T, transverse colon; D, descending colon; S, sigmoid colon; R, rectum; LGD, low-grade dysplasia; HGD, high-grade dysplasia; MSI, microsatellite instability-high, with more than two microsatellite mutations.

  • * Mutations are shown by the number of the codon involved and the sequence of the mutated codon.