Table 1.

Characteristics of non-Hispanic White BRCA mutation carriers with and without invasive breast cancer, by mutation status

BRCA1 mutation carriers
BRCA2 mutation carriers
Cases* (n = 195), n (%)Controls* (n = 302), n (%)Cases* (n = 128), n (%)Controls* (n = 179), n (%)
Reference age (y)
    <3023 (12)80 (27)10 (8)34 (19)
    30-3988 (45)107 (35)61 (48)60 (34)
    40-4984 (43)115 (38)57 (44)85 (47)
Year of birth
    1940-194916 (8)30 (10)16 (13)34 (19)
    1950-1959103 (53)87 (29)61 (48)53 (30)
    1960-196965 (33)98 (32)49 (38)56 (31)
    1970+11 (6)87 (29)2 (1)36 (20)
Study site
    Australia91 (47)121 (40)65 (51)91 (51)
    Canada47 (24)15 (5)35 (27)13 (7)
    United States42 (21)81 (27)22 (17)43 (24)
    (except Utah)15 (8)85 (28)6 (5)32 (18)
    Utah
Ascertainment
    Clinic based120 (62)284 (94)76 (59)158 (88)
    Population based75 (38)18 (6)52 (41)21 (12)
College graduate66 (34)119 (39)38 (30)65 (36)
Ever married146 (89)186 (79)86 (88)112 (90)
Family history114 (58)229 (76)67 (52)127 (71)
Age at menarche (y)
    <1395 (50)114 (38)46 (37)71 (40)
    1357 (30)78 (26)37 (30)65 (36)
    ≥1439 (20)106 (36)42 (33)42 (24)
Parous§145 (75)199 (66)101 (79)142 (79)
Estrogen receptor status, cases only
    Positive33 (17)70 (55)
    Negative111 (57)19 (15)
    Unknown51 (26)39 (30)
Progesterone receptor status, cases only
    Positive39 (20)65 (51)
    Negative98 (50)22 (17)
    Unknown58 (30)41 (32)
  • * The totals for the different variables may not equal to the total number of subjects in a category because of missing data.

  • For cases, age at breast cancer diagnosis and for controls, age at the earliest of these events: bilateral mastectomy, bilateral oopherectomy, diagnosis of in situ breast cancer, and interview.

  • Having first-degree relatives with breast cancer or ovarian cancer.

  • § Livebirths and stillbirths.