Table 4.

Biomarkers of exposure in all investigated subjects divided according to different polymorphic genotypes

Polymorphic genotype/genotype subgroupst,t-MA T0 μg/L, median (min-max), nt,t-MA T1 (μg/L), median (min-max), nS-PMA T1 (μg/L), median (min-max), nU-benzene T0 (ng/L), median (min-max), nU-benzene T1 (ng/L), median (min-max), n
CYP2E1 (RsaI)
    Wild-type76 (<10-1,850), 38279 (<10-1,089), 3826.7 (0.2-182.2), 340458 (77-6,430), 189283 (15-5,111), 194
    ht variant118 (<10-2,014), 2758 (<10-286), 285.6 (0.2-16.0), 28264 (72-6,235), 13149 (54-1,170), 14
    P*0.050.140.230.090.03
CYP2E1 (DraI)
    Wild-type74 (<10-1,850), 34977 (<10-1,089), 3496.6 (0.2-182.2), 308450 (77-6,430), 173273 (25-5,111), 177
    ht + ho variant115 (<10-2,014), 6088 (<10-452), 616.7 (0.2-18.5), 60347 (72-6,235), 29251 (15-3,296), 31
    P*0.020.690.750.630.46
NQO1
    Wild-type87 (<10-2,014), 23884 (<10-1,089), 2396.6 (0.2-182.2), 212421 (72-6,430), 115248 (25-4,246), 121
    ht + ho variant67 (<10-672), 17172 (<10-909), 1716.5 (0.2-65.9), 156466 (81-5,106), 87283 (15-5,111), 87
    P*0.400.400.780.690.96
  • NOTE: Comparison between genotype subgroups was done by t test for independent samples.

  • * P for comparison with t test for independent samples on log10-transformed variables between the genotype subgroups.