Table 1.

Reported correlations between organochlorine compound levels and BMI at time of biological sample collection relative to 1972 (the year that DDT use was banned in the United States) from selected reports, including recent breast cancer studies and earlier studies with reported correlations

No. years between 1972 and year of sample collectionCorrelation coefficient of BMI withBiological* sampleStudy design
DDEPCB
−7(Negative)(Negative)Blood serumJames et al. (16): Cohort study of pregnant women; PCBs were sum of nine penta-heptaCBs
4−0.11AdiposeWolff and Anderson (15): Cross-sectional, females, all ages, Michigan farm residents seen in 1976; “higher PCBs” measured by sum-of-area comparison to Aroclor 1254 for penta-heptaCBs (not congener specific)
40.18AdiposeWolff and Anderson (15); Cross-sectional, males, all ages, Michigan farm residents 1976; PCBs as in ref. 15
6−0.014−0.2Blood serumWolff et al. (19); Cross-sectional, all ages, Michigan general population; PCBs as in ref. 15
8−0.20−0.23AdiposeWolff and Anderson (15); Cross-sectional, females, all ages, Michigan farm residents seen in 1980; PCBs as in ref. 15
80.340.22AdiposeWolff and Anderson (15); Cross-sectional, males, all ages, Michigan farm residents seen in 1980; PCBs as in ref. 15
10(Positive)(Negative)Blood serumDorgan et al. (14); Breast cancer nested case-control study; PCBs were sum of 27 tri-octaCBs
150−0.29Blood serumWolff et al. (13); Breast cancer case-control study; PCBs were sum of 16 penta-heptaCBs
18(Positive)0Blood serumLaden et al. (12); Breast cancer cohort study; PCBs were sum of 16 penta-heptaCBs
240.03−0.23Blood serumMoysich et al. (11); Breast cancer case-control study
20(Positive)Adiposevan't Veer et al. (10); Breast cancer case-control study
210.12−0.17Blood serumMillikan et al. (9); Breast cancer case-control study, blacks; PCBs were sum of 35 tetra-octaCBs
210.09−0.08Blood serumMillikan et al. (9); Breast cancer case-control study, Whites
230.350.10Blood serumStellman et al. (8); Breast cancer case-control study; PCBs were sum of 14 tri-heptaCBs
240.21−0.15Blood serumWolff et al. (7); Breast cancer case-control study; PCBs were sum of 16 penta-heptaCBs
250.20−0.11Blood serumGammon et al. (6) (This study); Breast cancer case-control study; PCBs were sum of four highest PCBs (nos. 118, 138, 153, and 180)
  • * Organochlorine compound values were lipid based or lipid adjusted in correlations and analyses, with the exception of ref. 19.

  • Additional unpublished data from the study population in refs. 15 and 19 as indicated.

  • These correlations were not age adjusted. The correlations were age-adjusted Spearman, Pearson, or multiple regression coefficients.