Table 3.

Association of glioma and meningioma with polymorphisms in p53: promoter region (rs2287499), exon 4, codon 72 (rs1042522), and intron 6 (rs1625895), according to family history of cancer

GenotypeNo family history of cancer
Family history of cancer*
Glioma
Meningioma
Controls (n)Glioma
Meningioma
Controls (n)
nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
Promoter region
    CC1131.0 (reference)631.0 (reference)168521.0 (reference)551.0 (reference)115
    CG + GG230.71 (0.39-1.32)221.20 (0.67-2.14)49100.85 (0.38-1.89)151.21 (0.59-2.46)26
Exon 4, codon 72
    CC791.0 (reference)531.0 (reference)111371.0 (reference)321.0 (reference)96
    CG + CG560.85 (0.53-1.37)300.62 (0.36-1.04)102251.47 (0.79-2.74)352.39 (1.31-4.34)44
Intron 6
    CC1051.0 (reference)701.0 (reference)159481.0 (reference)541.0 (reference)111
    CT + TT260.80 (0.47-1.37)140.65 (0.34-1.25)49121.16 (0.54-2.50)171.46 (0.72-2.94)24
  • * Any type of cancer if first-degree relative based on information from questionnaire. In one glioma and six controls, there were no information of FHC and are excluded from Table 3 compared with Table 2.