Table 2.

Observed and expected triad genotype distributions among TGCC case-parent triads, by mating type and locus

Mating type*
Gene and polymorphism
M,F,CCYP1A2 −163C>A
CYP1B1Arg48Gly
CYP1B1Leu432Val
CYP1B1Asn453Ser
CYP3A4 −392A>G
CYP3A5 6986A>G
ObservedExpectedObservedExpectedObservedExpectedObservedExpectedObservedExpectedObservedExpected
1
    2,2,225250055000000
2
    2,1,21010.25224600.2500.2500.25
    2,1,11410.25328610.2510.2510.25
    1,2,2710.25126600.2500.2500.25
    1,2,11010.25226600.2500.2500.25
3
    2,0,16674.597.512.500.501
    0,2,16624.567.542.510.521
4
    1,1,234.543.2513801.750000.25
    1,1,110946.591643.50010.5
    1,1,054.553.2510831.750000.25
5
    1,0,111.513114548.757486.75
    1,0,011.5111125128.752456.75
    0,1,101.591185108.7574116.75
    0,1,041.511116598.750436.75
6
    0,0,011272788565689897070
Total103103101101104104104104107107101101
Maternal, RR- informative596159411830
Offspring, RR- informative656576431729
Definition of genotypes for each locus
    0CCCCCCAAAAGG
    1CACGCGAGAGGA
    2AAGGGGGGGGAA
  • NOTE: Expected numbers of triads under the null hypothesis that neither maternal nor offspring genotypes are associated with risk of TGCC.

  • * Mating types 2, 3, and 5 are informative for maternal RRs; mating types 2, 4, and 5 are informative for offspring RRs.

  • M, F, and C denote maternal, paternal, and case genotypes, respectively.