Table 4.

ORs for colorectal cancer and the 95% CIs according to tertile of fatty acid compositions (mol%) in erythrocyte membranes

OR (95% CI)* by tertiles
Ptrend
T1 (reference)T2T3
SFAs<50.89050.890-52.797>52.797
1.004.80 (1.84-12.52)8.20 (2.86-23.52)<0.0001
    14:0<0.6330.633-0.781>0.781
1.001.16 (0.56-2.41)1.66 (0.83-3.32)0.13
    16:0<29.17529.175-30.845>30.845
1.003.29 (1.32-8.19)6.46 (2.41-17.26)<0.0005
    18:0<20.70620.706-21.420>21.420
1.000.58 (0.28-1.19)0.84 (0.44-1.62)0.68
MUFAs<17.55517.555-18.850>18.850
1.002.07 (0.97-4.45)1.93 (0.88-4.23)0.15
    16:1n-7<0.8870.887-1.251>1.251
1.008.23 (2.94-23.03)5.99 (2.00-17.93)<0.01
    18:1n-9<16.66116.661-17.670>17.670
1.000.87 (0.44-1.74)1.01 (0.51-1.99)0.96
PUFAs§<28.20528.205-31.085>31.085
1.001.13 (0.57-2.23)0.15 (0.05-0.46)<0.005
    n-6 PUFAs<19.74319.743-21.506>21.506
1.000.71 (0.38-1.33)0.24 (0.10-0.59)<0.005
        18:2n-6<9.7349.734-10.892>10.892
1.000.85 (0.44-1.62)0.59 (0.28-1.23)0.16
        18:3n-6<0.0560.056-0.081>0.081
1.001.52 (0.68-3.39)2.54 (1.15-5.61)<0.05
        20:3n-6<0.6710.671-0.808>0.808
1.001.15 (0.59-2.23)1.10 (0.57-2.15)0.88
        20:4n-6 (AA)<8.6258.625-10.178>10.178
1.000.91 (0.48-1.73)0.42 (0.18-0.95)<0.05
    n-3 PUFAs<7.9757.975-9.745>9.745
1.001.40 (0.70-2.82)0.41 (0.15-1.09)0.16
        18:3n-3<0.2920.292-0.440>0.440
1.000.80 (0.40-1.62)1.18 (0.63-2.21)0.51
        n-3 HUFAs**<7.6397.639-9.221>9.221
1.001.27 (0.63-2.53)0.51 (0.21-1.25)0.20
            20:5n-3 (EPA)<1.1861.186-1.703>1.703
1.001.04 (0.52-2.07)0.69 (0.32-1.50)0.32
            22:5n-3<1.2371.237-1.508>1.508
1.001.29 (0.63-2.65)0.83 (0.34-2.05)0.81
            22:6n-3 (DHA)<5.0635.063-6.107>6.107
1.001.17 (0.58-2.36)0.36 (0.14-0.93)<0.05
Saturation index n-7††<24.25124.251-32.808>32.808
1.002.16 (1.10-4.26)0.28 (0.10-0.76)<0.01
Saturation index n-9‡‡<1.1771.177-1.272>1.272
1.001.02 (0.51-2.04)1.00 (0.50-1.99)0.99
SFAs/PUFAs<1.6401.640-1.860>1.860
1.009.65 (3.08-30.23)9.45 (2.84-31.43)<0.005
    SFAs/n-6 PUFAs<2.3592.359-2.675>2.675
1.003.79 (1.50-9.56)4.67 (1.80-12.10)<0.005
    SFAs/n-3 HUFAs<5.4805.480-6.901>6.901
1.003.77 (1.61-8.84)2.83 (1.08-7.37)0.14
n-6 PUFAs/n-3 PUFAs<2.1062.106-2.647>2.647
1.001.29 (0.63-2.62)0.84 (0.36-1.98)0.74
n-6 PUFAs/n-3 HUFAs<2.2092.209-2.800>2.800
1.001.22 (0.60-2.47)0.89 (0.39-2.04)0.81
    AA/EPA§§<5.5115.511-8.035>8.035
1.001.21 (0.62-2.35)0.71 (0.32-1.57)0.38
    AA/DHA∥∥<1.5731.573-1.846>1.846
1.000.83 (0.38-1.80)1.23 (0.53-2.89)0.46
  • * Adjusted for BMI, habitual exercise, drinking and smoking status, green-yellow vegetable intake, and family history of colorectal cancer.

  • SFAs = 14:0 + 16:0 + 18:0.

  • MUFAs = 16:1n-7 + 18:1n-9.

  • § PUFAs = n-6 PUFAs + n-3 PUFAs.

  • n-6 PUFAs = 18:2n-6 + 18:3n-6 + 20:3n-6 + 20:4n-6 (AA).

  • n-3 PUFAs = 18:3n-3 + n-3 HUFAs.

  • ** n-3 HUFAs = 20:5n-3 (EPA) + 22:5n-3 + 22:6n-3 (DHA).

  • †† 16:0/16:1n-7.

  • ‡‡ 18:0/18:1n-9.

  • §§ 20:4n-6/20:5n-3.

  • ∥∥ 20:4n-6/22:6n-3.