Table 3.

Association between CYP11α variants and prostate cancer, in the entire family-based study sample, stratified by disease aggressiveness

CYP11αEntire sampleLow aggressive*High aggressive
Cases/controlsOR (95% CI)PCases/controlsOR (95% CI)PCases/controlsOR (95% CI)P
(tttta)n§
    None85 of 901.0040 of 421.0038 of 431.00
    One copy199 of 2180.86 (0.53-1.38)0.5287 of 920.72 (0.33-1.59)0.42100 of 1071.11 (0.59-2.11)0.75
    Two copies153 of 1700.84 (0.47-1.48)0.5460 of 730.59 (0.24-1.45)0.2586 of 891.21 (0.55-2.67)0.64
  • * Includes cases with Gleason score <7 and tumor stage <T2C and their brothers.

  • Includes cases with Gleason score ≥7 and/or tumor stage ≥T2C and their brothers.

  • Adjusted for age.

  • § Presence of 4 (tttta) repeat allele.