Table 3.

Association of aspirin and nonaspirin NSAID use with proximal colon, distal colon, and rectal cancer incidence, IWHS, 1992-2002

Proximal colon cancer
Distal colon cancer
Rectal cancer
No. casesMultivariable-adjusted HR*,95% CINo. casesMultivariable-adjusted HR*,95% CINo. casesMultivariable-adjusted HR*,95% CI
Aspirin use
    Never1201.00Referent341.00Referent281.00Referent
    ≤1 per week1190.780.60-1.02491.060.67-1.68421.260.76-2.09
    ≥2 per week1260.670.51-0.87491.040.67-1.63501.320.82-2.13
365132120
Nonaspirin NSAID use
    Never2361.00Referent801.00Referent701.00Referent
    ≤1 per week711.100.83-1.46291.290.83-2.00231.030.62-1.71
    ≥2 per week580.710.52-0.97230.880.54-1.42271.260.80-2.00
365132120
  • * Adjusted for age (continuous), BMI (continuous), WHR (continuous), calcium intake (continuous), multivitamin use (yes and no), estrogen use (current and not current), family history of colon cancer (yes and no), physical activity (low, medium, and high), and smoking status (current, former, and never).

  • Aspirin analyses are adjusted for nonaspirin NSAID use and nonaspirin NSAID use analyses are adjusted for aspirin use.