Table 3.

Unadjusted and adjusted means of mammographic density (95% confidence interval) in quartiles of enterolactone

Quartiles of plasma enterolactone
Ptrend
1 (<7.19 nmol/L)2 (7.20-16.59 nmol/L)3 (16.60-28.29 nmol/L)4 (>28.30 nmol/L)
All women (n = 616)153155154154
    Percentage mammographic density
        Unadjusted6.4 (5.4-7.8)6.7 (5.6-8.1)7.8 (6.5-9.4)9.5 (7.9-11.5)<0.01
        Adjusted8.2 (6.8-9.8)8.1 (6.7-9.7)8.5 (7.0-10.2)10.2 (8.5-12.2)0.05
    Absolute mammographic density (cm2)
        Unadjusted9.1 (7.5-11.0)9.6 (8.0-11.7)10.7 (8.8-13.0)12.9 (10.6-15.7)<0.01
        Adjusted11.2 (9.1-13.7)11.2 (9.1-13.7)11.5 (9.3-14.1)13.7 (11.2-16.8)0.12
Current postmenopausal hormone therapy users (n = 162)35404146
    Percentage mammographic density
        Unadjusted10.4 (7.4-14.5)12.6 (9.2-17.1)11.3 (8.3-15.4)13.4 (10.1-17.9)0.34
        Adjusted9.1 (6.4-13.1)11.2 (7.8-16.0)10.3 (7.2-14.7)11.8 (8.6-16.3)0.34
    Absolute mammographic density (cm2)
        Unadjusted14.2 (10.0-20.1)17.2 (12.4-23.8)16.3 (11.8-22.5)18.2 (13.5-24.7)0.35
        Adjusted13.0 (8.8-19.3)15.7 (10.7-23.2)15.1 (10.3-22.1)16.5 (11.7-23.3)0.40
Current postmenopausal hormone therapy nonusers (n = 454)118115113108
    Percentage mammographic density
        Unadjusted5.6 (4.5-6.9)5.4 (4.4-6.7)6.8 (5.5-8.5)8.2 (6.6-10.3)<0.01
        Adjusted7.0 (5.7-8.6)6.5 (5.3-8.1)6.8 (5.5-8.4)8.7 (7.0-10.8)0.12
    Absolute mammographic density (cm2)
        Unadjusted8.0 (6.4-10.0)7.9 (6.3-9.9)9.2 (7.3-11.5)11.1 (8.8-14.1)0.03
        Adjusted9.4 (7.5-11.9)8.9 (7.1-11.3)8.9 (7.0-11.3)11.4 (9.0-14.6)0.25
  • NOTE: Reported means are back transformed from estimated marginal means. Analyses are adjusted for age (tertiles), BMI (tertiles), full-term pregnancies (none, 1-2, 3, 4 or more), age at first birth (<20, 20-24, >24), and postmenopausal hormone therapy (current use/current nonuse).