Table 3.

Incidence rate, relative risk, and excess risk of specific types of lung cancer

Risk measureNever (95% CI)Former (95% CI)Current (95% CI)Pack-years of current smokers (95% CI)
<2020-3030-40≥40
Incidence rate*
    Squamous cell1.9 (1.1-3.1)6.2 (2.2-18.2)22.2 (7.9-61.9)11.0 (3.4-35.0)18.1 (6.0-54.5)25.0 (8.7-71.8)38.1 (13.4-107.8)
    Adenocarcinoma11.1 (8.3-14.8)13.3 (7.3-24.3)23.1 (13.3-40.0)13.2 (6.2-28.4)19.0 (9.6-37.7)24.2 (13.1-44.6)35.7 (19.8-64.2)
    Small cell0.5 (0.2-1.4)3.5 (0.4-27.3)11.1 (1.5-82.9)7.3 (0.9-61.1)6.4 (0.8-53.6)14.0 (1.8-107.0)18.7 (2.5-141.6)
    Other types2.3 (1.4-3.9)4.7 (1.7-13.3)7.8 (2.9-20.7)6.6 (2.0-21.6)4.6 (1.3-16.0)8.2 (2.8-23.8)13.5 (4.9-37.4)
Relative risk
    Squamous cell
        Age-adjusted1.0 (Reference)3.3 (1.9-5.8)11.9 (7.2-19.7)4.9 (2.6-9.3)8.2 (4.6-14.5)11.3 (6.7-19.1)17.2 (10.3-28.7)
        Multivariate1.0 (Reference)3.4 (2.0-5.9)11.7 (7.1-19.4)5.1 (2.7-9.6)8.3 (4.6-14.7)11.3 (6.7-19.3)16.7 (10.0-27.9)
    Adenocarcinoma
        Age adjusted1.0 (Reference)1.2 (0.9-1.6)2.1 (1.6-2.7)1.1 (0.7-1.7)1.5 (1.0-2.3)2.0 (1.4-2.7)2.9 (2.1-3.9)
        Multivariate1.0 (Reference)1.2 (0.9-1.7)2.1 (1.6-2.7)1.1 (0.7-1.8)1.6 (1.0-2.3)2.0 (1.4-2.8)2.9 (2.2-3.9)
    Small cell
        Age adjusted1.0 (Reference)6.8 (2.4-19.2)21.7 (8.0-58.4)12.1 (4.0-36.6)10.6 (3.5-32.1)23.2 (8.4-64.1)31.0 (11.4-84.8)
        Multivariate1.0 (Reference)7.0 (2.5-19.9)21.7 (8.0-58.5)12.6 (4.2-38.2)11.0 (3.6-33.2)23.7 (8.5-65.5)30.5 (11.1-83.7)
    Other types
        Age adjusted1.0 (Reference)2.0 (1.2-3.4)3.3 (2.1-5.3)2.4 (1.2-4.6)1.7 (0.8-3.4)3.0 (1.7-5.1)4.9 (3.0-8.0)
        Multivariate1.0 (Reference)2.0 (1.2-3.4)3.3 (2.0-5.2)2.4 (1.2-4.6)1.7 (0.8-3.4)3.0 (1.7-5.1)4.8 (2.9-7.9)
Excess risk
    Squamous cell
        Age adjustedReference4.3 (1.0-15.0)20.3 (6.8-58.8)8.7 (2.1-31.3)15.9 (4.7-50.7)22.8 (7.4-68.1)35.8 (12.1-104.1)
        MultivariateReference4.4 (0.9-17.1)19.7 (5.9-64.0)8.8 (1.9-34.9)15.6 (4.1-55.6)22.2 (6.5-74.5)33.8 (10.2-109.8)
    Adenocarcinoma
        Age adjustedReference2.2 (−1.0-9.5)12.0 (5.0-25.2)0.8 (−3.1-11.8)6.6 (0.3-21.1)11.8 (3.9-28.0)23.3 (10.5-47.6)
        MultivariateReference3.0 (−0.8-13.7)13.9 (4.9-34.4)1.2 (−2.9-16.4)7.8 (0.4-28.8)13.8 (3.9-38.4)26.7 (10.3-64.4)
    Small cell
        Age adjustedReference3.0 (0.3-25.9)10.6 (1.3-81.5)6.7 (0.7-59.4)5.8 (0.5-52.0)13.4 (1.6-105.4)18.1 (2.3-139.9)
        MultivariateReference2.9 (0.2-28.4)9.8 (1.1-86.5)6.4 (0.6-64.9)5.5 (0.5-56.3)12.5 (1.3-112.6)16.3 (1.8-144.3)
    Other types
        Age adjustedReference2.4 (0.3-9.3)5.4 (1.5-16.8)3.8 (0.4-16.9)1.9 (−0.3-11.4)5.4 (1.2-19.1)10.8 (3.3-32.7)
        MultivariateReference3.4 (0.3-16.4)7.5 (1.7-28.8)5.4 (0.4-29.5)2.6 (−0.3-19.6)7.6 (1.3-33.1)14.8 (3.6-55.7)
  • * Age-adjusted incidence per 100,000 person-years, standard Poisson regression analysis.

  • Relative risk modeled using standard Poisson regression analysis adjusted for age or for all covariates.

  • Excess risk per 100,000 person-years, adjusting for age or for all covariates (same as in case of relative risk); standard Poisson regression analysis.