Table 4.

Estimation of SCCHN risk (OR and 95% CI) associated with expression levels of NER proteins

Expression level*Cases
Controls
Crude OR (95% CI)Multivariate adjusted OR (95% CI)Multivariate adjusted OR (95% CI)
No. (%)No. (%)
ERCC1high17 (32)29 (50)2.12 (0.98-4.59)2.18 (0.91-5.24)0.78 (0.21-2.85)
low36 (68)29 (50)
XPAhigh15 (28)30 (49)2.45 (1.12-5.35)2.99 (1.22-7.47)2.01 (0.57-7.14)
low38 (72)31 (51)
XPChigh13 (24)31 (50)3.15 (1.42-7.01)2.46 (1.04-5.87)1.17 (0.31-4.41)
low41 (76)31 (50)
XPDhigh15 (29)29 (49)2.38 (1.09-5.24)3.02 (1.18-7.76)1.88 (0.50-7.01)
low37 (71)30 (51)
XPFhigh13 (23)31 (50)3.31 (1.49-7.33)5.29 (2.01-13.9)11.5 (2.32-56.6)
low43 (77)31 (50)
XPGhigh18 (33)30 (50)2.06 (0.96-4.38)1.56 (0.79-3.92)0.48 (0.13-1.74)
low37 (67)30 (50)
  • * Dichotomized based on median values of control subjects.

  • Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, and lymphocyte storage time.

  • Obtained from logistic regression model with adjustment for age, sex, race, smoking status, alcohol use, lymphocytes.